Lin Zhang

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University of Pittsburgh

United States

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Recent Grants

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BET degraders for improving colorectal cancer therapy

Open Date: 2021-04-01

Close Date: 2026-03-31

Grant: Close

Targeting defective necroptosis in colorectal cancer

Open Date: 2019-12-01

Close Date: 2024-11-30

Grant: Close

Role of necroptosis in colorectal cancer therapy

Open Date: 2019-06-01

Close Date: 2024-05-30

Grant: Close

Translation addiction and targeting in colon cancer

Open Date: 2018-01-01

Close Date: 2022-12-31

Grant: Close

Novel Mcl-1 inhibitors for overcoming therapeutic resistance in colorectal cancer

Open Date: 2017-06-05

Close Date: 2022-05-31

Articles (20)

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2021

Collaborators (4)

Jian Yu

Professor

University of Southern California

UNITED STATES

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Yi Huang

Associate Professor

Iowa State University

UNITED STATES

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Yong Lee

Professor

University of Pittsburgh

UNITED STATES

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Chaoyuan Kuang

Assistant Professor

UNITED STATES

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Lin Zhang

Research Interests

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Recent Grants

Articles (20)

Differential Response and Resistance to KRAS‐Targeted Therapy

Depletion of oxysterol-binding proteins by OSW-1 triggers RIP1/RIP3-independent necroptosis and sensitization to cancer immunotherapy.

Werner helicase as a therapeutic target in mismatch repair deficient colorectal cancer.

Low extracellular pH enhances TRAIL-induced apoptosis by downregulating Mcl-1 expression.

Mcl-1 is a Gatekeeper Molecule to Regulate the Crosstalk Between Ferroptotic Agent-Induced ER Stress and TRAIL-Induced Apoptosis.

Restoration of TFPI2 by LSD1 Inhibition Suppresses Tumor Progression and Potentiates Antitumor Immunity in Breast Cancer.

Comprehensive characterization of MCL-1 in patients with colorectal cancer: Expression, molecular profiles, and outcomes.

UNSEG: unsupervised segmentation of cells and their nuclei in complex tissue samples.

Inhibition of multiple CDKs potentiates colon cancer chemotherapy via p73-mediated DR5 induction

PUMA/RIP3 mediates chemotherapy response via necroptosis and local immune activation in colorectal cancer.

mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death.

Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer

Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.

Dual inhibition of BET and HAT/p300 suppresses colorectal cancer via DR5- and p53/PUMA-mediated cell death.

CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade.

BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade

Interferon b drives intestinal regeneration after radiation

Role of Receptor Interacting Protein (RIP) kinases in cancer.

Non-steroidal anti-inflammatory drugs induce immunogenic cell death in suppressing colorectal tumorigenesis.

Glucose deprivation-induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity.

Collaborators (4)

Jian Yu

Yi Huang

Yong Lee

Chaoyuan Kuang

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