Long-Sheng Chang

Professor

The Ohio State University College of Medicine

United States

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Long-Sheng Chang is a Professor at Ohio State University College of Medicine in the United States. His research primarily focuses on neurofibromatosis, including the molecular pathogenesis and therapeutic approaches for NF2-associated tumors. Recent studies explore various treatment strategies, including the effects of bi-steric inhibitors, proteasomal pathway modulation, and the utilization of natural compounds in tumor management.

Articles (8)

Year:

2024

Year:

2023

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2020

Collaborators (4)

Salvatore La Rosa

Chief Scientific Officer

UNITED STATES

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D. Bradley Welling

Walter Augustus Lecompte Distinguished Professor

Harvard Medical School

UNITED STATES

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Steven Angus

Assistant Professor

Indiana State University

UNITED STATES

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Katharine A. Collier

UNITED STATES

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Long-Sheng Chang

Research Interests

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Articles (8)

Preclinical evaluation of the third-generation, bi-steric mechanistic target of rapamycin complex 1-selective inhibitor RMC-6272 in <i>NF2</i>-deficient models.

Proteasomal pathway inhibition as a potential therapy for NF2-associated meningioma and schwannoma.

Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy.

Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK

Early phase clinical studies of AR‐42, a histone deacetylase inhibitor, for neurofibromatosis type 2‐associated vestibular schwannomas and meningiomas

Neurofibromatosis: Molecular Pathogenesis and Natural Compounds as Potential Treatments.

Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species.

Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas

Collaborators (4)

Salvatore La Rosa

D. Bradley Welling

Steven Angus

Katharine A. Collier

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