Loranne Agius

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Professor, Principal Investigator

Newcastle University

United Kingdom

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About

Professor Loranne Agius is a Principal Investigator at Newcastle University, UK. Her research primarily focuses on glucokinase activation, metabolic pathways associated with diabetes, and the effects of various metabolites on liver functions. Recent publications include studies on glucokinase activators and their implications for drug development, as well as the role of specific gene variants in metabolic diseases.

Recent Grants

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MICA: Exploring a new perspective on the mechanism of action of Glucokinase Activators in liver, a preclinical study

Open Date: 2017-01-16

Close Date: 2020-01-15

Articles (9)

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2025

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2023

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2020

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2020

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2020

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2020

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UNITED KINGDOM

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Loranne Agius

Research Interests

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Contact this professor

About

Recent Grants

Articles (9)

Glucokinase Activators. A Humbling Lesson in Drug Development

Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants

The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326.

Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge.

Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation

Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse

The Protective Role of the Carbohydrate Response Element Binding Protein in the Liver: The Metabolite Perspective.

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective

Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation

Collaborators (5)

Silvia Marin

Matthew Wright

Celine Cano

Lee H Reed

Quentin M. Anstee

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