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Lotta Happonen

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Group leader, PI of Structural Infection Medicine (STRIME)

Lund University

Sweden

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Professors in Sweden Professors in Biochemistry Biochemistry professors in Sweden

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Disordered bacterial proteins and their interactions with the human host

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Articles (18)

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2026

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2022

Collaborators (26)

Carlos Alberto Gueto-Tettay

Senior Scientist

Lund University

SWEDEN

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Matti Javanainen

Assistant Professor

University of Tampere

FINLAND

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Markku Varjosalo

University of Helsinki

FINLAND

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Tommi Kajander

University of Helsinki

FINLAND

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Marta Montes

Center for Applied Medical Research

SPAIN

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Mats Ohlin

Lund University

SWEDEN

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Hannah Åbacka

Lund University

SWEDEN

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Thomas Hellmark

Vice Dean, responsible for education

Lund University

SWEDEN

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Gustav Torisson

SWEDEN

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Johan Malmström

Professor

Lund University

SWEDEN

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Lisa I. Påhlman

Lund University

SWEDEN

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Eija Nissila

University of Helsinki

FINLAND

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Pontus Nordenfelt

Lund University

SWEDEN

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Karin Lindkvist

Professor in Cell biology

Lund University

SWEDEN

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Lars Malmström

Lund University

SWEDEN

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Jonathan Bogan

Professor

Yale University

UNITED STATES

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Hamed Khakzad

Junior Professor

Inria Centre de Recherche Nancy Grand Est

FRANCE

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Karita Haapasalo

University of Helsinki

FINLAND

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Oonagh Shannon

Senior Lecturer/Associate Professor

Malmö University

SWEDEN

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Elisabeth Hjortswang

Lund University

SWEDEN

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Sudeep Karki

University of Helsinki

FINLAND

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Kari Salokas

University of Helsinki

FINLAND

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Juha Huiskonen

Professor of Structural Biology

University of Helsinki

FINLAND

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Sebastian Wrighton

Medical University of Vienna

AUSTRIA

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Ville Paavilainen

Tenure Track Group Leader

University of Helsinki

FINLAND

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Salla Keskitalo

University of Helsinki

FINLAND

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Lotta Happonen

Research Interests

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Articles (18)

CFTR modulator therapy reshapes airway inflammation in cystic fibrosis: Insights from proteomics and machine learning

Host interactomes of Streptococcus oralis and Streptococcus gordonii exposed to saliva or serum

State-of-the-Art and Future Directions in Structural Proteomics

Quantification of Adaptive Immune Responses Against Protein-Binding Interfaces in the Streptococcal M1 Protein

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh<sub>47</sub> potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies

Streptolysin O accelerates the conversion of plasminogen to plasmin

Multimodal Mass Spectrometry Identifies a Conserved Protective Epitope in S. pyogenes Streptolysin O

Immunomodulating Enzymes from Streptococcus pyogenes—In Pathogenesis, as Biotechnological Tools, and as Biological Drugs

Reduced binding of apoE4 to complement factor H promotes amyloid-beta oligomerization and neuroinflammation

Multienzyme deep learning models improve peptide de novo sequencing by mass spectrometry proteomics

Molecular view of <scp>ER</scp> membrane remodeling by the Sec61/<scp>TRAP</scp> translocon

The intracellular helical bundle of human glucose transporter GLUT4 is important for complex formation with ASPL

Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence

Proteomic characterization of plasma in Lemierre's syndrome

The twin-arginine translocation system is vital for cell adhesion and uptake of iron in the cystic fibrosis pathogen Achromobacter xylosoxidans

IdeS, a secreted proteinase of Streptococcus pyogenes, is bound to a nuclease at the bacterial surface where it inactivates opsonizing IgG antibodies

Affinity-Purification Combined with Crosslinking Mass Spectrometry for Identification and Structural Modeling of Host-Pathogen Protein-Protein Complexes.

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function

Collaborators (26)

Carlos Alberto Gueto-Tettay

Matti Javanainen

Markku Varjosalo

Tommi Kajander

Marta Montes

Mats Ohlin

Hannah Åbacka

Thomas Hellmark

Gustav Torisson

Johan Malmström

Lisa I. Påhlman

Eija Nissila

Pontus Nordenfelt

Karin Lindkvist

Lars Malmström

Jonathan Bogan

Hamed Khakzad

Karita Haapasalo

Oonagh Shannon

Elisabeth Hjortswang

Sudeep Karki

Kari Salokas

Juha Huiskonen

Sebastian Wrighton

Ville Paavilainen

Salla Keskitalo

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