Luca Jovine

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Professor of Structural Biology

Karolinska Institutet

Sweden

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Professor Luca Jovine is a faculty member at Karolinska Institutet in Sweden. His research areas include structural biology with a focus on gamete fusion mechanisms, female nonhormonal contraception, and the genetic basis of hereditary hemorrhagic telangiectasia. Recent articles authored by Professor Jovine examine topics such as thrombin interactions in preeclampsia and advancements in machine learning for structural predictions.

Recent Grants

Grant: Close

Investigations of molecular mechanisms of the egg-coat formation and egg-sperm interaction involved in gamete recognition

Open Date: 2013-04-01

Close Date: 2016-03-31

Grant: Close

Molecular Basis of Mammalian Egg-Sperm Interaction

Open Date: 2011-01-01

Close Date: 2015-12-31

Grant: Close

Molecular basis of mammalian egg-sperm recognition

Open Date: 2010-08-01

Close Date: 2012-08-01

Grant: Close

EMBO Young Investigators Award 2009

Open Date: 2010-01-01

Close Date: 2012-12-31

Articles (16)

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2025

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2024

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2024

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2024

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2024

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2024

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2022

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2022

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2022

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2022

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2021

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2020

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2020

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2020

Collaborators (17)

Carmelo Bernabeu

Research Professor

SPAIN

Luca Jovine

Research Interests

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About

Recent Grants

Articles (16)

Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia

Structural basis of ZP2-targeted female nonhormonal contraception

Specifications of the ACMG/AMP Variant Curation Guidelines for Hereditary Hemorrhagic Telangiectasia Genes—ENG and ACVRL1

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

Mutations causing premature termination codons discriminate and generate cellular and clinical variability in HHT

ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries

Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH

Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins.

Complementing machine learning-based structure predictions with native mass spectrometry.

A Non-Synonymous Point Mutation in a WD-40 Domain Repeat of EML5 Leads to Decreased Bovine Sperm Quality and Fertility.

Using machine learning to study protein–protein interactions: From the uromodulin polymer to egg zona pellucida filaments

Mutational and phenotypic characterization of hereditary hemorrhagic telangiectasia.

Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.

Mammalian egg coat modifications and the block to polyspermy

Collaborators (17)

Carmelo Bernabeu

Arne Elofsson

samuela pasquali

Cecile Denis

Elisa Rossi

Michal Zigo

Ernest Turro

Claire Shovlin

Yonggang Lu

Jonathan Stephens

bin wu

Shunsuke Nishio

Alexander Schleiffer

Karl Kerns

Fyodor Alexeevich Kondrashov

Gavin Wright

Yehu Moran

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