Luca Laraia

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Associate Professor

Technical University of Denmark

Denmark

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About

Dr. Luca Laraia is an Associate Professor at the Technical University of Denmark. His research focuses on sterol transport proteins, synthesis of small molecules, and the design of natural product-inspired compounds. Recent publications include studies on ligand selectivity of transporters, the development of fluorescent probes, and the identification of biologically diverse compounds. He is known for his contributions to understanding cholesterol transport and its implications in leukemic dependencies.

Recent Grants

Grant: Close

Determining mechanisms of intracellular sterol transport with selective chemical probes

Open Date: 2021-09-01

Close Date: 2026-08-01

Grant: Close

Blocking cholesterol production through specific protein degradation

Open Date: 2020-10-01

Close Date: 2023-09-01

Grant: Close

DTU-Score - Open-access high-throughput screening core for biomedicine

Open Date: 2020-01-01

Close Date: 2024-12-01

Grant: Close

Unravelling the sterol-interacting proteome using limited proteolysis small molecule mapping

Open Date: 2019-01-01

Close Date: 2022-01-01

Grant: Close

Identifying oxysterol-interacting proteins through specific degradation

Open Date: 2019-01-01

Close Date: 2022-01-01

Articles (18)

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2025

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2022

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2021

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2021

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2021

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2021

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2021

Collaborators (15)

Anders Asbjørn Jensen

Professor

University of Copenhagen

DENMARK

Luca Laraia

Research Interests

Contact this professor

About

Recent Grants

Articles (18)

Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters

Identification of a Privileged Scaffold for Inhibition of Sterol Transport Proteins through the Synthesis and Ring Distortion of Diverse, Pseudo-Natural Products

Unifying principles for the design and evaluation of natural product-inspired compound collections

Unifying principles for the design and evaluation of natural product-inspired compound collections

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP

Fluorescent probes and degraders of the sterol transport protein Aster-A

Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library

Identification of Biologically Diverse Tetrahydronaphthalen‐2‐ols through the Synthesis and Phenotypic Profiling of Chemically Diverse, Estradiol‐Inspired Compounds

Redshifted and thermally bistable one-way quantitative hemithioindigo-derived photoswitches enabled by isomer-specific excited state intramolecular proton transfer

Identification of non-conventional small molecule degraders and stabilizers of squalene synthase

Identification of non-conventional small molecule degraders and stabilizers of squalene synthase

Thermal Proteome Profiling Reveals Distinct Target Selectivity for Differentially Oxidized Oxysterols

A Photochemical Microfluidic Reactor for Photosensitized [2+2] Cycloadditions

Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol‐Inspired Compound Collection

Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol‐Inspired Compound Collection

Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin

Pseudo Natural Products—Chemical Evolution of Natural Product Structure

Pseudo Natural Products—Chemical Evolution of Natural Product Structure

Collaborators (15)

Anders Asbjørn Jensen

Thomas Whitmarsh-Everiss

Mikkel Krell-Jørgensen

Muhammad Rafehi

Mariusz Kubus

Yaowen Wu

Cecilia Rossetti

Katrine Qvortrup

Asmus Ougaard Dohn

Trond Ulven

George Karageorgis

Alison Forrester

Martin Nielsen

Daniel Foley

Giulio Superti-Furga

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