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Luca Laraia

Associate Professor

Technical University of Denmark

Denmark

Has grant

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Research Interests

Organic Chemistry

30%

Pharmaceutical Chemistry

60%

Natural Product Synthesis

60%

Alkaloid Chemistry

30%

Lipid Chemistry

30%

Chemical Biology

30%

Organic Reactions

20%

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Recent Grants

Grant: Open

Determining mechanisms of intracellular sterol transport with selective chemical probes

Open Date: 2021-09-01

Close Date: 2026-08-01

Grant: Close

Blocking cholesterol production through specific protein degradation

Open Date: 2020-10-01

Close Date: 2023-09-01

Grant: Close

DTU-Score - Open-access high-throughput screening core for biomedicine

Open Date: 2020-01-01

Close Date: 2024-12-01

Grant: Close

Unravelling the sterol-interacting proteome using limited proteolysis small molecule mapping

Open Date: 2019-01-01

Close Date: 2022-01-01

Grant: Close

Identifying oxysterol-interacting proteins through specific degradation

Open Date: 2019-01-01

Close Date: 2022-01-01

Articles18

Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters

Article Link

Year:

2025

Identification of a Privileged Scaffold for Inhibition of Sterol Transport Proteins through the Synthesis and Ring Distortion of Diverse, Pseudo-Natural Products

Article Link

Year:

2025

Unifying principles for the design and evaluation of natural product-inspired compound collections

Article Link

Year:

2025

Unifying principles for the design and evaluation of natural product-inspired compound collections

Article Link

Year:

2025

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP

Article Link

Year:

2024

Fluorescent probes and degraders of the sterol transport protein Aster-A

Article Link

Year:

2024

Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library

Article Link

Year:

2023

Identification of Biologically Diverse Tetrahydronaphthalen‐2‐ols through the Synthesis and Phenotypic Profiling of Chemically Diverse, Estradiol‐Inspired Compounds

Article Link

Year:

2023

Redshifted and thermally bistable one-way quantitative hemithioindigo-derived photoswitches enabled by isomer-specific excited state intramolecular proton transfer

Article Link

Year:

2023

Identification of non-conventional small molecule degraders and stabilizers of squalene synthase

Article Link

Year:

2023

Identification of non-conventional small molecule degraders and stabilizers of squalene synthase

Article Link

Year:

2023

Thermal Proteome Profiling Reveals Distinct Target Selectivity for Differentially Oxidized Oxysterols

Article Link

Year:

2022

A Photochemical Microfluidic Reactor for Photosensitized [2+2] Cycloadditions

Article Link

Year:

2022

Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol‐Inspired Compound Collection

Article Link

Year:

2021

Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol‐Inspired Compound Collection

Article Link

Year:

2021

Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin

Article Link

Year:

2021

Pseudo Natural Products—Chemical Evolution of Natural Product Structure

Article Link

Year:

2021

Pseudo Natural Products—Chemical Evolution of Natural Product Structure

Article Link

Year:

2021

Collaborators15

Anders Asbjørn Jensen

Professor

University of Copenhagen

DENMARK

Thomas Whitmarsh-Everiss

Technical University of Denmark

DENMARK

Mikkel Krell-Jørgensen

Technical University of Denmark

DENMARK

Muhammad Rafehi

University Medical Center Göttingen

GERMANY

Mariusz Kubus

Technical University of Denmark

DENMARK

Yaowen Wu

Professor

Umeå Universitet

SWEDEN

Cecilia Rossetti

Technical University of Denmark

DENMARK

Katrine Qvortrup

Technical University of Denmark

DENMARK

Asmus Ougaard Dohn

ICELAND

Trond Ulven

Københavns Universitet

DENMARK

George Karageorgis

Head of Chemistry

Lhasa limited

UNITED KINGDOM

Alison Forrester

University of Namur

BELGIUM

Martin Nielsen

Associate Professor

Technical University of Denmark

DENMARK

Daniel Foley

Senior Lecturer

University of Canterbury

NEW ZEALAND

Giulio Superti-Furga

Professor of Medical Systems Biology

Medical University of Vienna

AUSTRIA

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