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Luca Simula

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Permanent Researcher (CRCN INSERM)

Institut Cochin

France

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IMAX: Investigating mitochondrial dynamics in tumor-derived exhausted T cell

Open Date: 2020-01-01

Close Date: 2020-12-01

Articles (10)

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2026

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2023

Collaborators (3)

Marie-Clotilde Alves-Guerra

Directeur de Recherche

Institut Cochin

FRANCE

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Marianne Mangeney

CNRS Délégation Ile-de-France Sud

FRANCE

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Biagio De Angelis

Dirigente Farmacista

Ospedale Pediatrico Bambino Gesù

ITALY

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Luca Simula

Research Interests

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Recent Grants

Articles (10)

Fructose metabolism in pancreatic ductal adenocarcinoma: emerging vulnerabilities in KRAS G12D tumors and therapeutic perspectives with sodium citrate

Citrate-mediated control of chromatin and mitosis

An in vivo CRISPR screen unveils promising target genes to improve CAR-T cell efficacy in a solid tumor model.

Degrading cancer cell mitochondria to improve T cell-mediated killing

Inhibition of Atg7 in intestinal epithelial cells drives resistance against Citrobacter rodentium

Why and how citrate may sensitize malignant tumors to immunotherapy.

Mitochondrial metabolism sustains CD8+ T cell migration for an efficient infiltration into solid tumors

FOXO1 Inhibition Generates Potent Nonactivated CAR T Cells against Solid Tumors

The potential for citrate to reinforce epigenetic therapy by promoting apoptosis

The dual role of citrate in cancer.

Collaborators (3)

Marie-Clotilde Alves-Guerra

Marianne Mangeney

Biagio De Angelis

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