Luke Lairson

Associate Professor

Scripps Research Institute

United States

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Luke Lairson is an Associate Professor at the Scripps Research Institute in the United States. His research primarily focuses on STING activation, immunotherapy, and the effects of various small molecules and ligands on cellular phenotypes. Recent publications highlight advancements in chemotherapy resistance, antitumor immunity, and substrate-binding protein interactions.

Articles (15)

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2025

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2021

Collaborators (2)

Sendurai Mani

Professor

Brown University

UNITED STATES

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Matthew Griffin

Assistant Professor

University of California, Irvine

UNITED STATES

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Luke Lairson

Research Interests

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Articles (15)

Distinct oligomeric assemblies of STING induced by non-nucleotide agonists

Induced cell phenotype activity recording of DNA-tagged ligands

JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma

A new road to STING activation

Human Hsp70 Substrate-Binding Domains Recognize Distinct Client Proteins

Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A

Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators

A Cell Type Selective YM155 Prodrug Targets Receptor-Interacting Protein Kinase 2 to Induce Brain Cancer Cell Death

Targeting STING to promote antitumor immunity

Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers.

Promoting remyelination: A case study in regenerative medicine

Cover Feature: Towards an Understanding of the Molecular Mechanisms of Variable Unnatural Base‐Pair Behavior: A Biophysical Analysis of dNaM‐dTPT3 (Chem. Eur. J. 56/2021)

Towards an Understanding of the Molecular Mechanisms of Variable Unnatural Base‐Pair Behavior: A Biophysical Analysis of dNaM‐dTPT3

Modulators of immunoregulatory exonucleases PLD3 and PLD4 identified by high-throughput screen

HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins

Collaborators (2)

Sendurai Mani

Matthew Griffin

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