Luke Wiley

Assistant Professor

Iowa State University

United States

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About

Luke Wiley is an Assistant Professor at the University of Iowa, USA. His research focuses on retinal diseases and gene therapy, with recent studies on the effects of adeno-associated viruses on retinal inflammation, CRISPR-mediated treatments for retinitis pigmentosa, and the characterization of retinal degenerative models. He has also explored the biocompatibility of stem cell-derived retinal progenitor cells and gene transfer vectors for retinal conditions.

Articles (12)

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2020

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2020

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2020

Collaborators (4)

Budd Tucker

Associate Professor

Iowa State University

UNITED STATES

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Stephen Russell

Dina J. Schrage Professor for Macular Degeneration Research

University of Iowa Healthcare

UNITED STATES

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Elliott Sohn

Associate Professor (with tenure)

University of Iowa Hospitals and Clinics

UNITED STATES

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Timothy M. Boyce

UNITED STATES

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Luke Wiley

Research Interests

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Articles (12)

The Degree of Adeno-Associated Virus-Induced Retinal Inflammation Varies Based on Serotype and Route of Delivery: Intravitreal, Subretinal, or Suprachoroidal

Characterization of a novel Pde6b-deficient rat model of retinal degeneration and treatment with adeno-associated virus (AAV) gene therapy

CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa

Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa

Autoimmune retinopathy mimicking heritable retinal degeneration in a patient with common variable immune deficiency

Biocompatibility of Human Induced Pluripotent Stem Cell–Derived Retinal Progenitor Cell Grafts in Immunocompromised Rats

Choroidal endothelial and macrophage gene expression in atrophic and neovascular macular degeneration

The effect of retinal scaffold modulus on performance during surgical handling

Chimeric Helper-Dependent Adenoviruses Transduce Retinal Ganglion Cells and Müller Cells in Human Retinal Explants

Development of High-Resolution Three-Dimensional-Printed Extracellular Matrix Scaffolds and Their Compatibility with Pluripotent Stem Cells and Early Retinal Cells

Retinal Tropism and Transduction of Adeno-Associated Virus Varies by Serotype and Route of Delivery (Intravitreal, Subretinal, or Suprachoroidal) in Rats

Collaborators (4)

Budd Tucker

Stephen Russell

Elliott Sohn

Timothy M. Boyce

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