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Macarena Hernández Jiménez

Profesor Ayudante Doctor

Universidad Complutense de Madrid

Spain

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Research Interests

Pharmacology

50%

Pharmacotherapy

30%

Ischemic Stroke

30%

Aptamer

20%

Inflammatory Biology

20%

Neuroprotection

20%

Therapeutic Target

20%

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Articles14

Changes in Infarct Volume and Cerebral Edema After Mechanical Thrombectomy in Patients With Stroke Randomized to ApTOLL or Placebo: A Secondary Analysis of APRIL Trial

Article Link

Year:

2025

Aptamers as new promising entities for therapeutics: our experience from the neurological diseases

Article Link

Year:

2025

Cerebroprotective Effects of the TLR4-Binding DNA Aptamer ApTOLL in a Rat Model of Ischemic Stroke and Thrombectomy Recanalization

Article Link

Year:

2024

Gut Microbiota, Bacterial Translocation, and Stroke: Current Knowledge and Future Directions

Article Link

Year:

2024

ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis

Article Link

Year:

2024

Safety and Efficacy of ApTOLL in Patients With Ischemic Stroke Undergoing Endovascular Treatment

Article Link

Year:

2023

APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke.

Article Link

Year:

2023

Beneficial effect of TLR4 blockade by a specific aptamer antagonist after acute myocardial infarction.

Article Link

Year:

2023

Defective hippocampal neurogenesis underlies cognitive impairment by carotid stenosis-induced cerebral hypoperfusion in mice

Article Link

Year:

2023

Enhancing Enrollment in Acute Stroke Trials: Current State and Consensus Recommendations

Article Link

Year:

2023

First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers.

Article Link

Year:

2022

Defining a Target Population to Effectively Test a Neuroprotective Drug.

Article Link

Year:

2021

Influence of metabolic syndrome on post-stroke outcome, angiogenesis and vascular function in old rats determined by dynamic contrast enhanced MRI.

Article Link

Year:

2020

Targeting TLR4 with ApTOLL Improves Heart Function in Response to Coronary Ischemia Reperfusion in Pigs Undergoing Acute Myocardial Infarction.

Article Link

Year:

2020

Collaborators8

JESUS PRADILLO

LECTURER AND RESEARCHER

Universidad Complutense de Madrid

SPAIN

OLIVIA HURTADO

Profesor Titular Universidad

Universidad Complutense de Madrid

SPAIN

MARIA LAURA GARCIA-BERMEJO

SPAIN

Joan Montaner

Universidad de Sevilla

SPAIN

Maria Castelló-Ruiz

Senior Lecturer

University of Valencia

SPAIN

María del Mar Castellanos

Head of Neurological Department

Complejo Hospitalario de Pontevedra

SPAIN

María Hernández-Pérez

Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol

SPAIN

Spencer D Proctor

University of Alberta

CANADA

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