Mandar Naik

Assistant Professor (Research)

Brown University

United States

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Mandar Naik is an Assistant Professor (Research) at Brown University in the United States. His research focuses on neurobiology and biochemistry, with recent work exploring signaling mechanisms in Angelman Syndrome, diabetic retinopathy, and neurodegenerative conditions. His publications include studies on peptidomimetic inhibitors, RNA polymerase II interactions, and the structural properties of plant-derived renewable materials.

Articles (10)

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2025

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2024

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2024

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2024

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2024

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2023

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2020

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2020

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2020

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2020

Collaborators (2)

Christoph Schorl

Brown University

UNITED STATES

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Craig Kaplan

University of Pittsburgh

UNITED STATES

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Mandar Naik

Research Interests

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Articles (10)

Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model

Thiolutin has complex effects in vivo but is a direct inhibitor of RNA polymerase II in vitro

Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy

Targeting the postsynaptic scaffolding protein PSD-95 enhances BDNF signaling to mitigate depression-like behaviors in mice

Structure‐based design of peptidomimetic inhibitors of PSD‐95 with improved affinity for the PDZ3 domain

Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain

SARS-CoV-2 nucleocapsid protein phase-separates with RNA and with human hnRNPs.

Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid-liquid phase separation and aggregation.

Discovering Biomass Structural Determinants Defining the Properties of Plant-Derived Renewable Carbon Fiber.

Predicting the viability of beta-lactamase: How folding and binding free energies correlate with beta-lactamase fitness.

Collaborators (2)

Christoph Schorl

Craig Kaplan

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