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Manon Defaye

Has grant

Assitant professor

Laval University

Canada

Research Interests

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Professors in Canada Professors in Immunology Immunology professors in Canada

Recent Grants

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The gut microbiome controls chronic post-inflammatory pain via STING

Open Date: 2024-04-01

Close Date: 2025-10-01

Grant: Close

Role of TRPV1 colonic neurons in this microbiota-gut-brain axis in chronic visceral pain

Open Date: 2020-03-01

Close Date: 2022-03-01

Articles (19)

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2026

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Collaborators (10)

Bruce A. Vallance

CANADA

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Lukas Mager

Principal Investigator

University of Calgary

CANADA

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Joseph Schlessinger

Yale University

UNITED STATES

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Kevan Jacobson

Division Head

The University of British Columbia

CANADA

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Marie-Eve Tremblay

CANADA

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Yasmin Nasser

Assistant Professor

University of Calgary

CANADA

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Nicholas J. B. Brereton

University College Dublin

IRELAND

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Yves De Koninck

Professor

Laval University

CANADA

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Keith A. Sharkey

CANADA

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Louis-Etienne Lorenzo

Université Laval

CANADA

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Manon Defaye

Research Interests

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Recent Grants

Articles (19)

Mechanisms of chronic abdominal pain in inflammatory bowel disease and implications for treatment

Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents.

Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer.

The gut microbiota promotes pain in fibromyalgia

Médecine de la douleur

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis

Mo1318: ALKAL2/ALK AXIS MEDIATES PERSISTENT VISCERAL HYPERSENSITIVITY FOLLOWING COLITIS

Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells

Uncovering the therapeutic potential of anti-tuberculoid agent Isoniazid in a model of microbial-driven Crohn’s disease

Entourage effects of nonpsychotropic cannabinoids on visceral sensitivity in experimental colitis

Neuroimmunophysiology of the Gastrointestinal Tract.

Sex-specific post-inflammatory dysbiosis mediates chronic visceral pain in colitis

Spare the pain for your gut Treg cells!

Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice

Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection

A199 ALKAL2/ALK AXIS PROMOTE PERSISTENT VISCERAL PAIN

29 SEX-SPECIFIC GUT MICROBIOTA DIFFERENCES IN POST-INFLAMMATORY VISCERAL PAIN

A52 SEX DIFFERENCES IN POST-INFLAMMATORY VISCERAL PAIN IN A MOUSE MODEL OF INFLAMMATORY BOWEL DISEASE (IBD)

Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain

Collaborators (10)

Bruce A. Vallance

Lukas Mager

Joseph Schlessinger

Kevan Jacobson

Marie-Eve Tremblay

Yasmin Nasser

Nicholas J. B. Brereton

Yves De Koninck

Keith A. Sharkey

Louis-Etienne Lorenzo

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