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Manuel Izquierdo

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Senior Researcher

Consejo Superior de Investigaciones Cientificas

Spain

Research Interests

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Professors in Spain Professors in Cell Biology Cell Biology professors in Spain

Recent Grants

Grant: Close

Study of the molecular bases involved in the traffic of multivesicular bodies and exosome secretion in T lymphocytes: role in apoptosis and migration of T lymphocytes.

Open Date: 2016-12-01

Close Date: 2019-12-01

Grant: Close

Role of Diacylglycerol kinase α (DGKα), DGKζ, PKCδ and PKD1/2 in the polarized secretion of exosomes by T and B lymphocytes: Involvement of exosomes in apoptosis in the immune system.

Open Date: 2012-01-01

Close Date: 2014-12-01

Grant: Close

Study of the molecular bases involved in the polarized secretory traffic of exosomes in T lymphocytes: role of FMNL1 formin and actin cytoskeleton reorganization (Lymphoexosomes)

Open Date:

Close Date:

Articles (10)

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2026

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2026

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2025

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2025

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2025

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2024

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2024

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2024

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2023

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2023

Collaborators (5)

Lucía Fernández-Casanova

Staff Scientist

Centro Nacional de Investigaciones Oncológicas

SPAIN

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Juan Manuel Zapata Hernández

Scientific Researcher/head of Department

Consejo Superior de Investigaciones Cientificas

SPAIN

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ELISA FERNÁNDEZ MILLÁN

Contracted Lecturer

Universidad Complutense de Madrid

SPAIN

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Natalia Nieto

UNITED STATES

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Maria Angeles Moro

Catedrática de Universidad

Universidad Complutense de Madrid

SPAIN

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Manuel Izquierdo

Research Interests

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Recent Grants

Articles (10)

Image analysis of mitochondria during T lymphocyte and chimeric antigen receptor (CAR) effector responses

NKG2D-CAR memory T cells target pediatric T-cell acute lymphoblastic leukemia in vitro and in vivo but fail to eliminate leukemia initiating cells

Effect of lipotoxic hepatocyte-derived extracellular vesicles in pancreas inflammation: essential role of macrophage TLR4 in beta cell functionality

Tandem CD19/CD22 CAR T-cells as potential therapy for children and young adults with high-risk r/r B-ALL

Imaging the immune synapse: Three-dimensional analysis of the immune synapse

Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations

Formin-like 1β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse in Jurkat T lymphocytes

Extracellular vesicles and microvilli in the immune synapse

Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance

End-binding protein 1 regulates the metabolic fate of CD4<SUP>+</SUP> T lymphoblasts and Jurkat T cells and the organization of the mitochondrial network

Collaborators (5)

Lucía Fernández-Casanova

Juan Manuel Zapata Hernández

ELISA FERNÁNDEZ MILLÁN

Natalia Nieto

Maria Angeles Moro

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