Marco Viceconti

Aseptic loosening is the most common failure mode for total hip arthroplasty, and the design of the implant plays a significant role in influencing the longevity and stability of the implant. Finite Element (FE) models have been demonstrated to be powerful numerical tools that allow for generating information supporting the device’s safety and/or efficacy during pre-clinical assessment. Different authors have proposed FE studies aiming to simulate the long-term stability of the femoral stem; however, multiple improvements are still necessary for translating computational methodologies into clinical practice. This paper provides a comprehensive overview of the modelling procedures for predicting aseptic loosening risk, focusing on cementless femoral stems. The main modelling assumptions, including bone and implant geometry, materials, boundary conditions, and bone–implant interface contact, were summarised and presented. The limitations of various modelling assumptions and their impact on the simulation results were also discussed. The analysis suggests that more rigorous clinical validation for osseointegration models and failure criteria used to determine loosening of the implant should be clearly defined, and efforts should be made to identify the appropriate limit of tolerable conditions.