Marcus Schewe

Kiel University

Germany

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Articles (11)

Year:

2025

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2025

Year:

2025

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2024

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2024

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2024

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2023

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2022

Year:

2022

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2021

Year:

2020

Collaborators (7)

Simon Newstead

University of Oxford

UNITED KINGDOM

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Els Pardon

Vrije Universiteit Brussel

BELGIUM

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Caroline Wright

Professor

University of Exeter

UNITED KINGDOM

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Han Sun

W2 professor

Technische Universität Berlin

GERMANY

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Stephen Tucker

Professor of Biophysics

University of Oxford

UNITED KINGDOM

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Volker Straub

Newcastle University

UNITED KINGDOM

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Ehsan Nematian-Ardestani

AUSTRIA

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Marcus Schewe

Research Interests

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Articles (11)

Atomistic mechanism of non-canonical voltage gating in K2P channels

Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics

Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation

Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels

Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2

Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation

Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea

The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate

Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel

Collaborators (7)

Simon Newstead

Els Pardon

Caroline Wright

Han Sun

Stephen Tucker

Volker Straub

Ehsan Nematian-Ardestani

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