Margaret Freeberg
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United StatesResearch Interests
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Recent Grants
Grant: Close
Mechanotransduction regulation of cellular metabolism in pulmonary fibrosis
Open Date: 2024-09-01
Close Date: 2026-08-31
Grant: Open
Piezo2 as a novel mechanosensosr in the pathogenesis of fibrosis
Open Date: 2024-07-01
Close Date: 2027-06-01
Grant: Close
Targeting Mechano-sensors and Altered Metabolism in Lung Fibrosis
Open Date: 2021-10-01
Close Date: 2023-09-30
Grant: Close
Tissue stiffness promotes pro-fibrotic metabolic dysregulation in lung fibrosis
Open Date: 2020-12-01
Close Date: 2022-11-30
Articles (8)
Year:
2025
Year:
2025
Year:
2025
Year:
2024
We report that exhaled breath condensate (EBC) identifies cellular metabolic dysregulation in patients with radiation-induced lung injury. In this pilot study, untargeted metabolomics revealed a striking metabolic signature in EBC from patients with radiation-induced lung fibrosis compared to patients with lung cancer, at-risk smokers, and healthy volunteers. Patients with radiation-induced fibrosis exhibit specific changes in tricarboxylic acid (TCA) cycle energy metabolism that may be required to support the increased energy demands of fibroproliferation.
Year:
2023
Year:
2023
Year:
2021
Year:
2020
Collaborators (5)
Thomas Thatcher
Assistant Professor
Virginia Commonwealth University
Rebecca L. Heise
Virginia Commonwealth University
David Nagel
Assistant Professor
University of Rochester Medical Center
Patricia J. Sime
Virginia Commonwealth University
Andrew Dylag
Assistant Professor
University of Rochester
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