Maria Letizia Barreca

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Associate Professor in Medicinal Chemistry

University of Perugia

Italy

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About

Maria Letizia Barreca is an Associate Professor in Medicinal Chemistry at the University of Perugia, Italy. Her research focuses on the design and synthesis of small molecule drugs targeting viral polymerases and antimicrobial resistance. Recent articles include studies on anti-influenza A compounds and novel inhibitors for the Staphylococcus aureus NorA efflux pump. She is also involved in developing innovative methods for bioactivity data curation and exploring therapeutic strategies for precision cancer therapy.

Recent Grants

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Blocking the Neurotoxic Activities of Mutant Prion Proteins by a Novel Class of Therapeutic Agents

Open Date: 2022-01-01

Close Date:

Grant: Close

Development of "precision" agropharmaceuticals by means of the innovative PPI-FIT technology

Open Date: 2022-01-01

Close Date:

Grant: Close

Development of drugs capable of promoting cellular degradation of the prion protein

Open Date: 2021-01-01

Close Date:

Grant: Close

Identification of the Pharmacological Target of Compounds Modulating the Activity of the Cellular Prion Protein (CHEMPRION)

Open Date: 2021-01-01

Close Date:

Grant: Close

Tuning the Precision Oncology on the PI3K/ AKT/mTOR pathway

Open Date: 2021-01-01

Close Date: 2022-01-01

Articles (12)

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2024

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2024

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2023

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2023

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2023

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2022

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2022

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2021

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2021

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2021

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2021

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2020

Collaborators (16)

Graziano Lolli

Associate professor

University of Trento

ITALY

Maria Letizia Barreca

Research Interests

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About

Recent Grants

Articles (12)

Small Molecule Drugs Targeting Viral Polymerases

Switching the three-component Biginelli-like reaction conditions for the regioselective synthesis of new 2-amino[1,2,4]triazolo[1,5-a]pyrimidines

Identification of Anti-Influenza A Compounds Inhibiting the Viral Non-Structural Protein 1 (NS1) Using a Type I Interferon-Driven Screening Strategy

Fighting Antimicrobial Resistance: Insights on How the Staphylococcus aureus NorA Efflux Pump Recognizes 2-Phenylquinoline Inhibitors by Supervised Molecular Dynamics (SuMD) and Molecular Docking Simulations

Small Molecules Targeting DNA Polymerase Theta (POLθ) as Promising Synthetic Lethal Agents for Precision Cancer Therapy

Q-raKtion: A Semiautomated KNIME Workflow for Bioactivity Data Points Curation

Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity

Pharmacological inactivation of the prion protein by targeting a folding intermediate

From quinoline to quinazoline-based S. aureus NorA efflux pump inhibitors by coupling focused scaffold hopping approach and pharmacophore search

1,2,4-Triazolo [1, 5-a] pyrimidines: Efficient One-step Synthesis and Functionalization as Influenza Polymerase PA-PB1 Interaction Disruptors

Sustainable, three-component, one-pot procedure to obtain active anti- flavivirus agents

The Compelling Demand for an Effective PrP<sup>C</sup>-Directed Therapy against Prion Diseases

Collaborators (16)

Graziano Lolli

Emiliano Biasini

Giovanni Spagnolli

Mattia Sturlese

Serena Massari

Gianmarco Mangiaterra

Giuseppe Manfroni

Andrea Astolfi

Chiara Bertagnin

Gianluca Petris

Mariangela Agamennone

Maria Pennuto

Violetta Cecchetti

Luise Linsenmeier

Stefano Moro

Stefano Sabatini

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