Mario Shields

Associate Professor

Stony Brook University

United States

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About

Dr. Mario Shields is an Associate Professor at Stony Brook University in the United States. His research primarily focuses on pancreatic cancer, including the investigation of novel therapeutic strategies involving immune modulation and targeted therapies. Recent publications highlight his work on enhancing anti-PD-1 efficacy in chemotherapy-primed pancreatic cancer cells and developing preclinical models for immunotherapy studies.

Articles (7)

Year:

2024

Year:

2024

Year:

2024

Year:

2022

Year:

2022

Year:

2021

Year:

2020

Collaborators (3)

Rodolfo Lavilla

Full professor

University of Barcelona

SPAIN

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Sonja Vermeren

Reader

University of Edinburgh

UNITED KINGDOM

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Daniel R. Principe

UNITED STATES

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Mario Shields

Research Interests

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Articles (7)

Trametinib Potentiates Anti-PD-1 Efficacy in Tumors Established from Chemotherapy-Primed Pancreatic Cancer Cells.

Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer.

BET Inhibition Rescues Acinar-Ductal-Metaplasia and Ciliogenesis and Ameliorates Chronic Pancreatitis-Driven Changes in Mice With Loss of the Polarity Protein Par3.

Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8+ T cell antitumor immunity

Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin.

Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies.

A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis.

Collaborators (3)

Rodolfo Lavilla

Sonja Vermeren

Daniel R. Principe

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