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Mark Brimble

Assistant Professor

University of Washington Medical Center

United States

Research Interests

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Articles (13)

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2026

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2026

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2026

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2025

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2024

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2024

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2024

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2024

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2024

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2024

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2024

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2024

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2023

Collaborators (6)

Aisha Souquette

Research Associate Professor

University of Maryland

UNITED STATES

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Gisella Vetere

Professor

ESPCI ParisTech

FRANCE

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Tomás Ryan

Professor

Trinity College Dublin

IRELAND

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Mel Cosentino

Aarhus University

DENMARK

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gilda stefanelli

Assistant professor

University of Ottawa

CANADA

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Andressa Monteiro Venturini

Stanford University

UNITED STATES

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Mark Brimble

Research Interests

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Articles (13)

Splice isoforms of the histone variant macroH2A1 differentially regulate hippocampal gene expression and memory formation.

Deconstruction of a memory engram reveals distinct ensembles recruited at learning

Rational engineering of the P5 TRS-mimic site and REP78/68 start codon yields promoter variants that improve rAAV purity while maintaining high titers.

Extinction and subsequent updating of innate fear responses to a visual looming stimulus rely on hippocampus-dependent mechanisms

Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification

Threat-dependent scaling of prelimbic dynamics to enhance fear representation

Preventing bad behavior in academia

Pre-Existing Immunity to a Nucleic Acid Contaminant-Derived Antigen Mediates Transaminitis and Resultant Diminished Transgene Expression in a Mouse Model of Hepatic Recombinant Adeno-Associated Virus-Mediated Gene Transfer

Non-encapsidated miRNA contaminants found in AAV preparations

Single cell and TCR analysis of immune cells from AAV gene therapy-dosed Duchenne muscular dystrophy patients.

rAAV expressing a COBRA-designed influenza hemagglutinin generates a protective and durable adaptive immune response with a single dose.

The role of the m6A/m demethylase FTO in memory is both task and sex-dependent in mice.

Stowaways in the cargo: Contaminating nucleic acids in rAAV preparations for gene therapy

Collaborators (6)

Aisha Souquette

Gisella Vetere

Tomás Ryan

Mel Cosentino

gilda stefanelli

Andressa Monteiro Venturini

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