Mark Chappell

Professor

Wake Forest School of Medicine

United States

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Mark Chappell is a Professor at Wake Forest University School of Medicine in the United States. His research primarily focuses on the renin-angiotensin system, its implications in COVID-19, and the associated sex differences in metabolic responses. He has authored several recent articles investigating the endocrine significance of SARS-CoV-2, vasoplegia during cardiopulmonary bypass, and the biochemical characterization of supplements.

Articles (12)

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2025

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2025

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2025

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2023

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2020

Collaborators (3)

Ivor Douglas

Prof. of Medicine

University of Colorado Anschutz Medical Campus

UNITED STATES

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Katherine Cook

Associate Professor

Wake Forest University

UNITED STATES

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Christopher Schaich

Assistant Professor

Wake Forest School of Medicine

UNITED STATES

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Mark Chappell

Research Interests

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Articles (12)

Attenuated renin response and reduced angiotensin II concentrations: association with cardiopulmonary bypass-induced vasoplegia

The circulating renin-angiotensin system and mortality among patients hospitalized for COVID-19: a mechanistic substudy of the ACTIV-4 Host Tissue trials

Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients

Renin-Angiotensin System and Sex Differences in COVID-19: A Critical Assessment

Discrete Correlation Summation Clustering Reveals Differential Regulation of Liver Metabolism by Thrombospondin-1 in Low-Fat and High-Fat Diet-Fed Mice

Targeted UHPLC-MS Analysis Reveals Disparate Polyphenol Composition and Concentration in Muscadine Grape Supplements with Proportional Antioxidant Activity

The Renin–Angiotensin–Aldosterone System in COVID-19–related and Non–COVID-19–related Acute Respiratory Distress Syndrome: Not So Different after All?

A pilot study to assess the circulating renin-angiotensin system in COVID-19 acute respiratory failure

Endocrine significance of SARS-CoV-2’s Reliance on ACE2

Concerns on the Specificity of Commercial ELISAs for the Measurement of Angiotensin (1–7) and Angiotensin II in Human Plasma

S1P (Site-1 Protease)-Induced Release of the Soluble Prorenin Receptor in Hypertension

COVID-19, ACE2, and the cardiovascular consequences

Collaborators (3)

Ivor Douglas

Katherine Cook

Christopher Schaich

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