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Mark J. Zylka

University of North Carolina at Chapel Hill

United States

Research Interests

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Articles (14)

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2026

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2026

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2026

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2024

Collaborators (5)

Lawrence S. Engel

University of North Carolina

UNITED STATES

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Jason L Stein

Associate Professor

University of North Carolina at Chapel Hill

UNITED STATES

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Samhitha Pudipeddi

University of North Carolina at Chapel Hill

UNITED STATES

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Martin Scheffner

(Full) Professor of Biochemistry

University of Konstanz

GERMANY

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Kelly Vanden

University of California, San Diego

UNITED STATES

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Mark J. Zylka

Research Interests

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Articles (14)

Nickase NmCas9 unsilences paternal Ube3a in a mouse model of Angelman syndrome without causing AAV vector integration

Crossing the finish line towards a disease-modifying treatment for Angelman syndrome

Multi-targeting zinc finger nuclease vector unsilences paternal UBE3A in a mouse model of Angelman syndrome

The environmental neuroactive chemicals list of prioritized substances for human biomonitoring and neurotoxicity testing: A database and high-throughput toxicokinetics approach

Compact Calm1 promoter enables AAV mediated neuron-targeted expression in human iPSC-derived brain organoids

Evaluating the efficacy of neurokinin-1 (substance P) receptor antagonist CP-99994 on facial grimacing and allodynia in mice postsurgery: a comparative study with known analgesics

A luminescence-based biosensor to measure endogenous UBE3A activity

Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons

AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription

Single nucleus RNA sequencing of the cerebral cortex from genetically diverse inbred mouse strains reveals differences in pericyte and endothelial cell composition

Identifying environmental chemicals impacting neurodevelopment using a random mixture-based screening approach

Enhanced facial grimacing when laparotomy involves cutaneous and visceral tissue injury

Exploring the Cytoplasmic Retention of CRISPR-Cas9 in Eukaryotic Cells: The Role of Nuclear Localization Signals and Ribosomal Interactions

Development of PainFace software to simplify, standardize, and scale up mouse grimace analyses

Collaborators (5)

Lawrence S. Engel

Jason L Stein

Samhitha Pudipeddi

Martin Scheffner

Kelly Vanden

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