Mark Skehel

Head

The Francis Crick Institute

United Kingdom

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About

Mark Skehel is the Head at The Francis Crick Institute in the UK. His research interests encompass ribosome function, protein biogenesis, and the molecular mechanisms of diseases, as evidenced by his recent publications on COVID-19 protease inhibitors and neurodegenerative diseases. He is particularly focused on the dynamics of the proteome and novel therapeutic approaches using chemoproteomics and modular screening techniques.

Articles (10)

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2025

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2025

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2025

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2025

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2025

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2024

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2023

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2022

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2021

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2021

Collaborators (3)

Michael Harvey Hastings

Programme Leader (former Head of Division, 2013- 2023)

MRC Laboratory of Molecular Biology

UNITED KINGDOM

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Alan Murphy

Imperial College London

UNITED KINGDOM

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Leonardo Almeida-Souza

University of Helsinki

FINLAND

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Mark Skehel

Research Interests

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Articles (10)

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking

Multi‐Omic Analysis Reveals Astrocytic Annexin‐A2 as Critical for Network‐Level Circadian Timekeeping in the Suprachiasmatic Nucleus

Expedited SARS‐CoV‐2 Main Protease Inhibitor Discovery through Modular ‘Direct‐to‐Biology’ Screening

Expedited SARS‐CoV‐2 Main Protease Inhibitor Discovery through Modular ‘Direct‐to‐Biology’ Screening

Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation

Mechanism of single-stranded DNA annealing by RAD52–RPA complex

Checkpoint kinase interaction with DNA polymerase alpha regulates replication progression during stress

Multidimensional Dynamics of the Proteome in the Neurodegenerative and Aging Mammalian Brain

Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins

Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation

Collaborators (3)

Michael Harvey Hastings

Alan Murphy

Leonardo Almeida-Souza

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