Martin Ruthardt

Senior Lecturer in Haematology

Cardiff University

United Kingdom

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Martin Ruthardt is a Senior Lecturer in Haematology at Cardiff University, United Kingdom. His research focuses on the molecular mechanisms underlying acute myeloid leukemia, particularly the activation of signaling pathways related to specific genetic mutations. Recent articles authored by Dr. Ruthardt investigate the interactions of high-risk leukemia drivers, the efficacy of ABL1 inhibitors like crizotinib, and the role of mesenchymal factors in drug resistance in chronic myelogenous leukemia.

Articles (4)

Year:

2022

Year:

2022

Year:

2021

Year:

2020

Collaborators (2)

Oliver Hantschel

University of Marburg

GERMANY

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Ricardo M. Biondi

GERMANY

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Martin Ruthardt

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Articles (4)

Activation of signaling pathways in models of t(6;9)-acute myeloid leukemia.

Understanding a high-risk acute myeloid leukemia by analyzing the interactome of its major driver mutation.

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1<sup>T315I</sup> and BCR-ABL1<sup>T315I-E255K</sup>.

Mesenchymal soluble factors confer imatinib drug resistance in chronic myelogenous leukemia cells.

Collaborators (2)

Oliver Hantschel

Ricardo M. Biondi

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