Mary Jo Ondrechen

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Professor

Northeastern University

United States

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About

Mary Jo Ondrechen is a Professor at Northeastern University in the United States. Her research focuses on enzymatic catalysis, structural genomics, and biochemical characterization of disease-associated variants, with recent publications exploring the dynamics and electrostatics of human phosphoglucose isomerase and the functional annotation of various proteins. She utilizes computational chemistry to identify active sites in enzymes and has contributed to the study of cancer-associated variants in DNA polymerase Kappa.

Recent Grants

Grant: Close

Role of Coupled Amino Acids in the Mechanisms of Enzyme Catalysis

Open Date: 2022-07-01

Close Date: 2025-06-30

Grant: Close

Control of Activity in ERK2 Kinase: Computational Studies of the Normal Enzyme and a Cancer Variant

Open Date: 2021-09-01

Close Date: 2022-01-01

Grant: Close

RAPID: D3SC: Identification of Chemical Probes and Inhibitors Targeting Novel Sites on SARS-CoV-2 Proteins for COVID-19 Intervention

Open Date: 2020-05-15

Close Date: 2022-04-30

Grant: Close

RAPID: Undergraduate Research in Modeling and Computation for Discovery of Molecular Probes for SARS-CoV-2 Proteins

Open Date: 2020-05-01

Close Date: 2023-04-30

Grant: Close

Phase II: Lighting the Pathway to Faculty Careers for Natives in STEM

Open Date: 2019-09-01

Close Date: 2024-08-31

Articles (15)

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2025

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2022

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2022

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2022

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2022

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2021

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2021

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2020

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2020

Collaborators (3)

Cathleen Zeymer

Tenure Track Assistant Professor

Ludwig-Maximilians-Universität München

GERMANY

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Ann Kimble-Hill

Assistant Research Professor

Indiana University School of Medicine

UNITED STATES

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George O'Doherty

Professor

Northeastern University

UNITED STATES

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Mary Jo Ondrechen

Research Interests

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About

Recent Grants

Articles (15)

Distal residues contribute to enzymatic catalysis in human phosphoglucose isomerase through modulation of dynamics and electrostatics

Cartilage targeting cationic peptide carriers display deep cartilage penetration and retention in a rabbit model of post-traumatic osteoarthritis

Biochemical Characterization of Disease-Associated Variants of Human Ornithine Transcarbamylase

Revisiting the Roles of Catalytic Residues in Human Ornithine Transcarbamylase

Biochemical Activity of 17 Cancer-Associated Variants of DNA Polymerase Kappa Predicted by Electrostatic Properties

Functional annotation of haloacid dehalogenase superfamily structural genomics proteins

Enzyme active sites: Identification and prediction of function using computational chemistry

Electrostatic fingerprints of catalytically active amino acids in enzymes

Stereoselective Synthesis of β-Glycinamide Ribonucleotide

Functional Characterization of Structural Genomics Proteins in the Crotonase Superfamily

Best Practices to Diversify Chemistry Faculty

Analysis of electrostatic coupling throughout the laboratory evolution of a designed retroaldolase

Amino acid interactions that facilitate enzyme catalysis

Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2

Probing remote residues important for catalysis in Escherichia coli ornithine transcarbamoylase

Collaborators (3)

Cathleen Zeymer

Ann Kimble-Hill

George O'Doherty

Make your next move.

Mary Jo Ondrechen

Research Interests

Explore related searches

Contact this professor

About

Recent Grants

Articles (15)

Distal residues contribute to enzymatic catalysis in human phosphoglucose isomerase through modulation of dynamics and electrostatics

Cartilage targeting cationic peptide carriers display deep cartilage penetration and retention in a rabbit model of post-traumatic osteoarthritis

Biochemical Characterization of Disease-Associated Variants of Human Ornithine Transcarbamylase

Revisiting the Roles of Catalytic Residues in Human Ornithine Transcarbamylase

Biochemical Activity of 17 Cancer-Associated Variants of DNA Polymerase Kappa Predicted by Electrostatic Properties

Functional annotation of haloacid dehalogenase superfamily structural genomics proteins

Enzyme active sites: Identification and prediction of function using computational chemistry

Electrostatic fingerprints of catalytically active amino acids in enzymes

Stereoselective Synthesis of &beta;-Glycinamide Ribonucleotide

Functional Characterization of Structural Genomics Proteins in the Crotonase Superfamily

Best Practices to Diversify Chemistry Faculty

Analysis of electrostatic coupling throughout the laboratory evolution of a designed retroaldolase

Amino acid interactions that facilitate enzyme catalysis

Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2

Probing remote residues important for catalysis in Escherichia coli ornithine transcarbamoylase

Collaborators (3)

Cathleen Zeymer

Ann Kimble-Hill

George O'Doherty

Make your next move.

Stereoselective Synthesis of β-Glycinamide Ribonucleotide