Massimiliano Runfola

University of Oxford

United Kingdom

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Articles (17)

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2025

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2024

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2023

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2023

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2020

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2020

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2020

Collaborators (8)

Grazia Chiellini

University of Pisa

ITALY

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Valeria La Pietra

University of Naples Federico II

ITALY

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Amedeo Columbano

Professor

University of Cagliari

ITALY

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SIMONA SESTITO

University of Sassari

ITALY

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Gabriella Ortore

Associate Professor

University of Pisa

ITALY

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Simona Rapposelli

University of Pisa

ITALY

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Jin Hae Kim

Assistant professor

Daegu Gyeongbuk Institute of Science and Technology

SOUTH KOREA

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Laura Calza

Full Professor

University of Bologna

ITALY

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Massimiliano Runfola

Research Interests

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Articles (17)

Novel Thyroid Hormone Receptor-β Agonist TG68 Exerts Anti-Inflammatory, Lipid-Lowering and Anxiolytic Effects in a High-Fat Diet (HFD) Mouse Model of Obesity

Synthesis of Aryl-fused Bicyclo[3.1.1]heptanes (BCHeps) and Validation as Naphthyl Bioisosteres

Synthetic Thyroid Hormone Receptor-β Agonists Promote Oligodendrocyte Precursor Cell Differentiation in the Presence of Inflammatory Challenges

Synthetic Thyroid Hormone Receptor-β Agonists Promote Oligodendrocyte Precursor Cell Differentiation in the Presence of Inflammatory Challenges

Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids

Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids

TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD

Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer’s Disease

Diphenyl-Methane Based Thyromimetic Inhibitors for Transthyretin Amyloidosis

Beyond Antioxidant Effects: Nature-Based Templates Unveil New Strategies for Neurodegenerative Diseases

Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile

Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease

TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD

Diphenyl-Methane Based Thyromimetic Inhibitors for Transthyretin Amyloidosis

Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics

Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis

Endogenous 3-iodothyronamine (T1Am) and synthetic thyronamine-like analog SG-2 act as novel pleiotropic neuroprotective agents through the modulation of SIRT6

Collaborators (8)

Grazia Chiellini

Valeria La Pietra

Amedeo Columbano

SIMONA SESTITO

Gabriella Ortore

Simona Rapposelli

Jin Hae Kim

Laura Calza

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