Mathias Ziegler

Professor

University of Bergen

Norway

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Professor Mathias Ziegler is a faculty member at Universitetet i Bergen, Norway. His research focuses on NAD+ metabolism, mitochondrial dysfunction, and the implications of these areas in various clinical contexts. Recent publications highlight his work on the role of NAD+ in cellular processes, as well as novel applications and challenges in targeting NAD+ for therapeutic purposes.

Articles (20)

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2025

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2021

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2021

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2021

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2020

Collaborators (17)

Karla LH Feijs

RWTH Aachen University

GERMANY

Mathias Ziegler

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Articles (20)

Emerging strategies, applications and challenges of targeting NAD+ in the clinic

Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation

Apigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages independently of CD38

GEMCAT—a new algorithm for gene expression-based prediction of metabolic alterations

Regulation of and challenges in targeting NAD+ metabolism

Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+

Evolution of fungal tuberculosis necrotizing toxin (TNT) domain‐containing enzymes reveals divergent adaptations to enhance NAD+ cleavage

Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by <i>POLG</i> Mutation.

Dynamics of SLC25A51 reveal preference for oxidized NAD+ and substrate led transport

Novel Calcium-Binding Motif Stabilizes and Increases the Activity of <i>Aspergillus fumigatus</i> Ecto-NADase

Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria

Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes-a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC-MS.

ADP-ribosyltransferases, an update on function and nomenclature.

Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD

Discovery of fungal surface NADases predominantly present in pathogenic species.

The balance between NAD<sup>+</sup> biosynthesis and consumption in ageing.

Instability in NAD<sup>+</sup> metabolism leads to impaired cardiac mitochondrial function and communication.

Welcome to the Family: Identification of the NAD<sup>+</sup> Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25

Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells.

SLC25A51 is a mammalian mitochondrial NAD+ transporter.

Collaborators (17)

Karla LH Feijs

Christopher Lord

Juha P. Kallio

Marcel Kwiatkowski

Janna Saarela

Geir Selbaek

Bernhard Lüscher

Magnus Monné

Toni Gossmann

Guy Poirier

Krzysztof Pawłowski

Jonas Treebak

Sebastian Guettler

marie migaud

Sebastian Deindl

Jason Matthews

Xiaolu Cambronne

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