Mathieu Vinken

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Vrije Universiteit Brussel

Belgium

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Recent Grants

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An animal-free approach for human safety testing of food additives

Open Date: 2021-10-01

Close Date: 2022-09-01

Grant: Close

ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment

Open Date: 2021-05-01

Close Date: 2026-04-01

Grant: Open

Cellular communication as target and biomarker in liver disease and toxicity: from basic research towards clinical application

Open Date: 2021-01-01

Close Date: 2027-12-01

Grant: Close

Are connexins, pannexins and their (hemi)channels novel biomarkers and pharmacological targets in the prognosis and therapy of liver cancer?

Open Date: 2020-01-01

Close Date: 2023-12-01

Grant: Close

PANACHE: production of next generation modulators of pannexins and connexins as novel therapeutics in the treatment of inflammatory cardiovascular, hepatic and joint diseases

Open Date: 2019-12-01

Close Date: 2023-12-01

Articles (28)

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Collaborators (32)

Robim Rodrigues

National Institute on Alcohol Abuse and Alcoholism

UNITED STATES

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Daniela Grimm

Professor

Otto-von-Guericke Universität Magdeburg

GERMANY

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Xavier Verhelst

Associate Professor of Hepatology

Ghent University

BELGIUM

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Joost Boeckmans

Vrije Universiteit Brussel

BELGIUM

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Yannick Gennady Lichterfeld

Deutsches Zentrum für Luft- und Raumfahrt

GERMANY

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Anne Marie Vinggaard

Technical University of Denmark

DENMARK

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Marth Stinckens

Vrije Universiteit Brussel

BELGIUM

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Li Shean Toh

Asst Professor

University of Nottingham

UNITED KINGDOM

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Alexandra Gatzios

Vrije Universiteit Brussel

BELGIUM

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Pierre Boutouyrie

INSERM

FRANCE

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Philip Marx-Stoelting

Scientific director/head of unit

Federal Institute for Risk Assessment (BfR)

GERMANY

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Ellen Callewaert

Vrije Universiteit Brussel

BELGIUM

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Annika Drees

Vrije Universiteit Brussel

BELGIUM

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Raf Van Campenhout

Vrije Universiteit Brussel

BELGIUM

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Hans Van Vlierberghe

Ghent University Hospital

BELGIUM

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Thomas Hartung

Professor and Chair

Johns Hopkins University Bloomberg School of Public Health

UNITED STATES

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Ralf L. M. Peeters

University of Maastricht

NETHERLANDS

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Ákos Bernard Jóźwiak

Head of Food and Nutrition Science

Systems Research Institute

HUNGARY

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Zenzi Rosseel

Vrije Universiteit Brussel

BELGIUM

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Milos Mihajlovic

Vrije Universiteit Brussel

BELGIUM

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Sinem Helvacıoglu

Vrije Universiteit Brussel

BELGIUM

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Tamara Vanhaecke

Vrije Universiteit Brussel

BELGIUM

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Anouk Verhoeven

Vrije Universiteit Brussel

BELGIUM

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Arthur Lamouroux

University of Bordeaux

FRANCE

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Amy Maerten

Vrije Universiteit Brussel

BELGIUM

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Brenda Kwak

Full professor

University of Geneva

SWITZERLAND

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Vera Rogiers

Vrije Universiteit Brussel

BELGIUM

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Joop Jonckheer

Vrije Universiteit Brussel

BELGIUM

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Anne Caufriez

Vrije Universiteit Brussel

BELGIUM

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Hendrik Reynaert

Vrije Universiteit Brussel

BELGIUM

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Andres Tabernilla

Vrije Universiteit Brussel

BELGIUM

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Elisabeth De Waele

Vrije Universiteit Brussel (VUB)

BELGIUM

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Mathieu Vinken

Research Interests

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Recent Grants

Articles (28)

Pharmacological countermeasures for long-duration space missions: addressing cardiovascular challenges and advancing space-adapted healthcare

Taking the 3Rs to a higher level: replacement and reduction of animal testing in life sciences in space research.

Present and future of Al, open science, and transparency in regulatory science

Mapping the ethical and sustainable transition in toxicology: a bibliometric analysis and a review of new approach methodologies

Animal-free Safety Assessment of Chemicals: Project Cluster for Implementation of Novel Strategies (ASPIS) definition of new approach methodologies

Optimization of the drug-induced cholestasis index based on advanced modeling for predicting liver toxicity

The Alarming Consequences of Workforce Reductions at the FDA, EPA, NIH and CDC in the United States

Hepatotoxicity in spaceflight: intrinsic and extrinsic risks for astronaut metabolic health

Mapping physiology: a systems biology approach for the development of alternative methods in toxicology

Design and synthesis of cyclic lipidated peptides derived from the C-terminus of Cx43 for hemichannel inhibition and cardiac endothelium targeting

Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures

Dataset on transcriptomic profiling of parenteral nutrition-induced hepatotoxicity in a human liver in vitro model

Parenteral nutrition-associated liver injury: clinical relevance and mechanistic insights

A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis

E-waste: mechanisms of toxicity and safety testing

Hepatic cell junctions: Pulling a double‐duty

Accessible methods and tools to estimate chemical exposure in humans to support risk assessment: a systematic scoping review

Corrigendum to “Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: Analysis of a database of 432 patients developed by literature review and machine learning support” [Biomed. Pharmacother. 174 (2024) 116530]

The application of natural language processing for the extraction of mechanistic information in toxicology

Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: analysis of a database of 432 patients developed by literature review and machine learning support

Pannexin1 channels in the liver: an open enemy.

Parenteral Nutrition, Sepsis, Acute Heart Failure and Hepatotoxic Drugs Are Related to Liver Test Disturbances in Critically Ill Patients

New Approach Methodologies in human regulatory toxicology – not if, but how and when!

Determination of structural features that underpin the pannexin1 channel inhibitory activity of the peptide 10Panx1

Unraveling the mechanisms underlying drug-induced cholestatic liver injury: identifying key genes using machine learning techniques on human in vitro data sets

Transient Kupffer cell depletion and subsequent replacement by infiltrating monocyte-derived cells does not alter the induction or progression of hepatocellular carcinoma

Kupffer Cells Contested as Early Drivers in the Pathogenesis of Primary Sclerosing Cholangitis

Unraveling Hepatic Metabolomic Profiles and Morphological Outcomes in a Hybrid Model of NASH in Different Mouse Strains

Collaborators (32)

Robim Rodrigues

Daniela Grimm

Xavier Verhelst

Joost Boeckmans

Yannick Gennady Lichterfeld

Anne Marie Vinggaard

Marth Stinckens

Li Shean Toh

Alexandra Gatzios

Pierre Boutouyrie

Philip Marx-Stoelting

Ellen Callewaert

Annika Drees

Raf Van Campenhout

Hans Van Vlierberghe

Thomas Hartung

Ralf L. M. Peeters

Ákos Bernard Jóźwiak

Zenzi Rosseel

Milos Mihajlovic

Sinem Helvacıoglu

Tamara Vanhaecke

Anouk Verhoeven

Arthur Lamouroux

Amy Maerten

Brenda Kwak

Vera Rogiers

Joop Jonckheer

Anne Caufriez

Hendrik Reynaert

Andres Tabernilla

Elisabeth De Waele

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