Matthew Disney

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Professor

Scripps Florida

United States

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Matthew Disney is a Professor at Scripps Florida in the United States. His research focuses on RNA–protein interactions, the development of small molecules targeting structured RNAs, and innovative strategies for cancer treatment. Recent publications highlight his work on RNA-reactive small molecules and the design of precision medicines guided by comprehensive transcriptome analysis.

Recent Grants

Grant: Close

Using a disease-affected cell to synthesize its own drug

Open Date: 2015-09-30

Close Date: 2020-07-31

Grant: Close

Sequence-based Design of Small Molecules Targeting RNA

Open Date: 2012-04-05

Close Date: 2020-03-31

Grant: Close

HTS to Identify Small Molecules Targeting Repeating Transcripts

Open Date: 2012-02-01

Close Date: 2014-01-31

Grant: Close

Identifying and Studying RNA Loop-Small Molecule Interactions

Open Date: 2008-08-01

Close Date: 2014-07-31

Articles (22)

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Collaborators (8)

Jonathan Rohrer

University College London

UNITED KINGDOM

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Philip Wong

Professor

Johns Hopkins University

UNITED STATES

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Robert Batey

Professor

University of Colorado Boulder

UNITED STATES

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Yanjun Li

Assistant Professor

University of Florida

UNITED STATES

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Lauren M Gittings

Research Assistant Professor

Barrow Neurological Institute

UNITED STATES

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Raphael I. Benhamou

ISRAEL

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ILYAS YILDIRIM

Assistant Professor

UNITED STATES

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Brian Paegel

Professor

University of California

UNITED STATES

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Matthew Disney

Research Interests

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About

Recent Grants

Articles (22)

A Live-Cell NanoBRET Assay to Monitor RNA–Protein Interactions and Their Inhibition by Small Molecules

Discovery of RNA-Reactive Small Molecules Guides the Design of Electrophilic Modules for RNA-Specific Covalent Binders

Streamlined Fragment-Based Discovery Platform for Targeting Structured RNAs

Linker Optimization Enhances the Potency of Ribonuclease-Targeting Chimeras in Cancer Models

The Druggable Transcriptome Project: From Chemical Probes to Precision Medicines

Mapping small molecule–RNA binding sites via Chem-CLIP synergized with capillary electrophoresis and nanopore sequencing

The evolution and application of RNA-focused small molecule libraries

Transcriptome-Wide, Unbiased Profiling of Ribonuclease Targeting Chimeras

Heterobifunctional small molecules to modulate RNA function

Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp Degrader in Myotonic Dystrophy

DNA‐Encoded Libraries and Their Application to RNA

Fragment-Based Approaches to Identify RNA Binders

Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit

Altering the Cleaving Effector in Chimeric Molecules that Target RNA Enhances Cellular Selectivity

Optimization of a Protein-Targeted Medicine into an RNA-Specific Small Molecule

Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion

Targeting RNA structures with small molecules

Low-Molecular Weight Small Molecules Can Potently Bind RNA and Affect Oncogenic Pathways in Cells

Bioinformatic Searching for Optimal RNA Targets of Dimeric Compounds Informs Design of a MicroRNA-27a Inhibitor

A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks

A Few Revolutions of the RNA World in ACS Publications

Systematically Studying the Effect of Small Molecules Interacting with RNA in Cellular and Preclinical Models

Collaborators (8)

Jonathan Rohrer

Philip Wong

Robert Batey

Yanjun Li

Lauren M Gittings

Raphael I. Benhamou

ILYAS YILDIRIM

Brian Paegel

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