Matthew Gentry

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Professor & Chair

University of Florida College of Medicine

United States

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Matthew Gentry is a Professor & Chair at the University of Florida College of Medicine, USA. His research focuses on glycogen-related disorders, including Lafora disease and Pompe disease, as well as the role of glycogen in cancer metabolism and neurodegenerative conditions. Recent articles highlight advancements in gene therapy and the therapeutic potential of small-molecule inhibitors targeting glycogen metabolism.

Recent Grants

Grant: Close

Defining glucan dikinase phosphorylation of starch from multiple kingdoms

Open Date: 2022-10-01

Close Date: 2023-09-30

Grant: Close

MRI: Acquisition of Hydrogen/Deuterium eXchange Mass Spectrometer

Open Date: 2022-10-01

Close Date: 2023-09-30

Grant: Open

Aberrant Glycogen in Lung Adenocarcinoma Tumorigenesis

Open Date: 2022-07-01

Close Date: 2027-06-30

Grant: Close

Safety and Biodistribution of a Novel Enzyme-Antibody Fusion in a Canine Model

Open Date: 2022-03-01

Close Date: 2024-08-31

Grant: Close

MRI: Acquisition of Hydrogen/Deuterium eXchange Mass Spectrometer

Open Date: 2020-08-01

Close Date: 2023-02-28

Articles (19)

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2020

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SPAIN

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Barry J. Byrne

Professor and Associate Chair

University of Florida

UNITED STATES

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Jordi Duran

Associate Professor and Principal Investigator

Universitat Ramon Llull IQS

SPAIN

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Matthew Gentry

Research Interests

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Recent Grants

Articles (19)

Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders

Effect of intracerebroventricular administration of alglucosidase alfa in two mouse models of Lafora disease: Relevance for clinical practice

Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis

The multifaceted roles of the brain glycogen

Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancer.

Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model.

Prognostic value of pathogenic variants in Lafora Disease: systematic review and meta-analysis of patient-level data.

Current avenues of gene therapy in Pompe disease.

Current avenues of gene therapy in Pompe disease

Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis.

Differential activity of glucan phosphatase starch EXcess4 orthologs from agronomic crops

Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer

Two Diseases—One Preclinical Treatment Targeting Glycogen Synthesis

Generation and characterization of a laforin nanobody inhibitor

The 6th International Lafora Epilepsy Workshop: Advances in the search for a cure

Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging

Polyglucosan body structure in Lafora disease

Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry

Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis

Collaborators (7)

Teresa Fan

Manuela Corti

Ramon Sun

THOMAS HURLEY

Reinald Pamplona

Barry J. Byrne

Jordi Duran

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