Matthew Lew

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Associate Professor

Washington University in St. Louis

United States

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About

Matthew Lew is an Associate Professor at Washington University in St. Louis, USA. His research areas focus on advanced microscopy techniques, specifically single-molecule orientation imaging and the structural analysis of biomolecular condensates, as highlighted in his recent publications. He has contributed to the understanding of amyloid fibrils and the interactions at RNA-based biomolecular interfaces through innovative imaging methodologies.

Recent Grants

Grant: Close

Livtronics: Living Electronics for Biologically-Enhanced Sensing, Computing, and Signal Transmission

Open Date: 2018-08-01

Close Date: 2021-07-31

Grant: Open

Six-Dimensional Single-Molecule Nanoscopy for Elucidating the Dynamic Organization of Biomolecules

Open Date: 2017-08-15

Close Date: 2028-04-30

Grant: Close

CAREER: Nanoscale sensing and imaging using computational single-molecule nanoscopy

Open Date: 2017-02-01

Close Date: 2023-01-31

Articles (20)

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2022

Collaborators (7)

Rohit Pappu

Gene K. Beare Distinguished Professor

Washington University in St. Louis

UNITED STATES

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Oumeng Zhang

Assistant Professor

Texas A&M University

UNITED STATES

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Daoyuan Qian

University of Cambridge

UNITED KINGDOM

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Tingting Wu

Washington University in St. Louis

UNITED STATES

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Bryce Sadtler

UNITED STATES

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Meikun Shen

University of Oregon

UNITED STATES

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Tianben Ding

Assistant Professor

University of Tokyo

JAPAN

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Matthew Lew

Research Interests

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About

Recent Grants

Articles (20)

Single-fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates

Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates

Correction to “Single-Molecule Orientation Imaging Reveals the Nano-Architecture of Amyloid Fibrils Undergoing Growth and Decay”

Single-molecule orientation and localization microscopy

Painting rich six-dimensional pictures using polarized fluorescence microscopy

Resolving the Orientations of and Angular Separation Between a Pair of Dipole Emitters

Resolving the Orientations of and Angular Separation between a Pair of Dipole Emitters

Resolving the Orientations of and Angular Separation Between a Pair of Dipole Emitters

BPS2025 - Nuclear speckle proteins undergo intrinsic and RNA-dependent microphase separation

BPS2025 - Nuclear speckle proteins undergo intrinsic and RNA-dependent microphase separation

A multi-view reflector microscope visualizes six-dimensional single-molecule translational and rotational dynamics with isotropic nanoscale resolution.

Mapping inhomogeneous network structures within biomolecular condensate using single-molecule imaging and tracking of fluorogenic probes.

Single-molecule orientation-localization microscopy resolves how amyloidophilic dye orientations are correlated with amyloid fiber growth and disruption.

Six-dimensional single-molecule imaging with isotropic resolution using a multi-view reflector microscope

Deep-SMOLM: deep learning resolves the 3D orientations and 2D positions of overlapping single molecules with optimal nanoscale resolution

Deep-SMOLM: deep learning resolves the 3D orientations and 2D positions of overlapping single molecules with optimal nanoscale resolution.

Towards optimal point spread function design for resolving closely spaced emitters in three dimensions

Towards optimal point spread function design for resolving closely spaced emitters in three dimensions.

In Situ Imaging of Catalytic Reactions on Tungsten Oxide Nanowires Connects Surface–Ligand Redox Chemistry with Photocatalytic Activity

Dipole-spread-function engineering for simultaneously measuring the 3D orientations and 3D positions of fluorescent molecules

Collaborators (7)

Rohit Pappu

Oumeng Zhang

Daoyuan Qian

Tingting Wu

Bryce Sadtler

Meikun Shen

Tianben Ding

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