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Matthew Lew

Associate Professor

Washington University in St. Louis

United States

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Research Interests

Condensed Matter Physics

50%

Medical Imaging

20%

Optical Physics

50%

Scanning Tunneling Microscopy

40%

Microscopy

40%

Super-resolution Microscopy

40%

Molecular Imaging

30%

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Recent Grants

Grant: Close

Livtronics: Living Electronics for Biologically-Enhanced Sensing, Computing, and Signal Transmission

Open Date: 2018-08-01

Close Date: 2021-07-31

Grant: Open

Six-Dimensional Single-Molecule Nanoscopy for Elucidating the Dynamic Organization of Biomolecules

Open Date: 2017-08-15

Close Date: 2028-04-30

Grant: Close

CAREER: Nanoscale sensing and imaging using computational single-molecule nanoscopy

Open Date: 2017-02-01

Close Date: 2023-01-31

Articles20

Single-fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates

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Year:

2025

Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates

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2025

Correction to “Single-Molecule Orientation Imaging Reveals the Nano-Architecture of Amyloid Fibrils Undergoing Growth and Decay”

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2025

Single-molecule orientation and localization microscopy

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2025

Painting rich six-dimensional pictures using polarized fluorescence microscopy

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2025

Resolving the Orientations of and Angular Separation Between a Pair of Dipole Emitters

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2025

Resolving the Orientations of and Angular Separation between a Pair of Dipole Emitters

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2025

Resolving the Orientations of and Angular Separation Between a Pair of Dipole Emitters

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Year:

2025

BPS2025 - Nuclear speckle proteins undergo intrinsic and RNA-dependent microphase separation

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2025

BPS2025 - Nuclear speckle proteins undergo intrinsic and RNA-dependent microphase separation

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2025

A multi-view reflector microscope visualizes six-dimensional single-molecule translational and rotational dynamics with isotropic nanoscale resolution.

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Year:

2023

Mapping inhomogeneous network structures within biomolecular condensate using single-molecule imaging and tracking of fluorogenic probes.

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2023

Single-molecule orientation-localization microscopy resolves how amyloidophilic dye orientations are correlated with amyloid fiber growth and disruption.

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2023

Six-dimensional single-molecule imaging with isotropic resolution using a multi-view reflector microscope

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Year:

2023

Deep-SMOLM: deep learning resolves the 3D orientations and 2D positions of overlapping single molecules with optimal nanoscale resolution

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Year:

2022

Deep-SMOLM: deep learning resolves the 3D orientations and 2D positions of overlapping single molecules with optimal nanoscale resolution.

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Year:

2022

Towards optimal point spread function design for resolving closely spaced emitters in three dimensions

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2022

Towards optimal point spread function design for resolving closely spaced emitters in three dimensions.

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2022

In Situ Imaging of Catalytic Reactions on Tungsten Oxide Nanowires Connects Surface–Ligand Redox Chemistry with Photocatalytic Activity

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Year:

2022

Dipole-spread-function engineering for simultaneously measuring the 3D orientations and 3D positions of fluorescent molecules

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Year:

2022

Collaborators7

Rohit Pappu

Gene K. Beare Distinguished Professor

Washington University in St. Louis

UNITED STATES

Oumeng Zhang

Assistant Professor

Texas A&M University

UNITED STATES

Daoyuan Qian

University of Cambridge

UNITED KINGDOM

Tingting Wu

Washington University in St. Louis

UNITED STATES

Bryce Sadtler

UNITED STATES

Meikun Shen

University of Oregon

UNITED STATES

Tianben Ding

Assistant Professor

University of Tokyo

JAPAN

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