Matthew Potthoff

Associate Professor

The University of Iowa Roy J and Lucille A Carver College of Medicine

United States

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Matthew Potthoff is an Associate Professor at the University of Iowa Carver College of Medicine in the United States. His research focuses on metabolic regulation, specifically the role of FGF21 and its signaling pathways in weight management and metabolic diseases. Recent publications include studies on the impact of genetic variations on body weight, central nervous system functions, and the interaction between liver-produced signals and metabolism.

Articles (13)

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2025

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2025

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2024

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2022

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2022

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2021

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2021

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2021

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2020

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2020

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2020

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2020

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2020

Collaborators (5)

Deniz Atasoy

Assistant Professor

The University of Iowa Roy J and Lucille A Carver College of Medicine

UNITED STATES

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Nirav Dhanesha

UNITED STATES

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Steven Lentz

Professor

The University of Iowa

UNITED STATES

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D. Thomas Rutkowski

The University of Iowa Roy J and Lucille A Carver College of Medicine

UNITED STATES

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Manasa Nayak

Research Assistant Professor

The University of Iowa

UNITED STATES

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Matthew Potthoff

Research Interests

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Articles (13)

Mice harboring the obesity-associated SNP rs1421085 exhibit increased body weight and reveal an IRX3 neuronal circuit regulating body weight

FGF21 reverses MASH through coordinated actions on the CNS and liver

Characterization of FGF21 Sites of Production and Signaling in Mice

Central FGF21 production regulates memory but not peripheral metabolism

Conditional gene targeting using UCP1-Cre mice directly targets the central nervous system beyond thermogenic adipose tissues

The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Metabolic Messengers: FGF21

Hepatokines and metabolism: Deciphering communication from the liver

FGF21 signaling in glutamatergic neurons is required for weight loss associated with dietary protein dilution.

FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake.

NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis.

Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide.

Adipose TBX1 regulates β-adrenergic sensitivity in subcutaneous adipose tissue and thermogenic capacity in vivo.

Collaborators (5)

Deniz Atasoy

Nirav Dhanesha

Steven Lentz

D. Thomas Rutkowski

Manasa Nayak

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