Matthew Young

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Tenured Associate Professor

SIU School of Medicine

United States

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Recent Grants

Grant: Close

Defining the cellular and molecular mechanisms of how toxicants disrupt mitochondrial DNA homeostasis

Open Date: 2021-08-04

Close Date: 2024-07-31

Grant: Close

The Roles of Polymerase Gamma Accessory Subunit Gene Mutations in Human Disease.

Open Date: 2016-05-01

Close Date: 2021-04-30

Articles (6)

Year:

2024

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Collaborators (1)

Deborah A. Court

Professor

University of Manitoba

CANADA

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Matthew Young

Research Interests

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Contact this professor

Recent Grants

Articles (6)

Our current understanding of the biological impact of endometrial cancer mtDNA genome mutations and their potential use as a biomarker

Heterozygous p.Y955C mutation in DNA polymerase γ leads to alterations in bioenergetics, complex I subunit expression, and mtDNA replication

Identification of Somatic Mitochondrial DNA Mutations, Heteroplasmy, and Increased Levels of Catenanes in Tumor Specimens Obtained from Three Endometrial Cancer Patients

A non‐radioactive DNA synthesis assay demonstrates that elements of the Sigma 1278b Mip1 mitochondrial DNA polymerase domain and C‐terminal extension facilitate robust enzyme activity

The antiretroviral 2′,3′-dideoxycytidine causes mitochondrial dysfunction in proliferating and differentiated HepaRG human cell cultures

Remdesivir triphosphate blocks DNA synthesis and increases exonucleolysis by the replicative mitochondrial DNA polymerase, Pol γ

Collaborators (1)

Deborah A. Court

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