Matthias Lehr

University of Münster

Germany

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Articles (16)

Year:

2025

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2025

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2025

Systematic structural variation of the cytosolic phospholipase A 2 α (cPLA 2 α) inhibitor 7, recently found in a ligand-based virtual screening approach, led to the 1-benzylindole derivative 122, which was about 300 times more potent than 7.

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2021

Collaborators (2)

Christoph Arenz

Professor

Humboldt-Universität zu Berlin

GERMANY

View details

Klaus Langer

Professor

Westfälische Wilhelms-Universität Münster

GERMANY

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Matthias Lehr

Research Interests

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Articles (16)

Inhibitors of Phosphatidylinositol-specific Phospholipase C with Myo-inositol Scaffold

Carbamates with ortho-Substituted O-Phenyl Groups as Dual Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: Inhibitory Potency, Hydrolytic Stability, and QSAR Studies

Quantitative profiling of lipid mediators in sperm cells through on-line dilution on-line polymer matrix-based solid-phase extraction liquid chromatography with mass spectrometric detection

1-Benzylindoles as inhibitors of cytosolic phospholipase A<sub>2</sub>α: synthesis, biological activity, aqueous solubility, and cell permeability

N,N-Disubstituted 4-Sulfamoylbenzoic Acid Derivatives as Inhibitors of Cytosolic Phospholipase A2α: Synthesis, Aqueous Solubility, and Activity in a Vesicle and a Whole Blood Assay

1-Benzylindoles as inhibitors of cytosolic phospholipase A2α: synthesis, biological activity, aqueous solubility, and cell permeability

Synthesis and pharmacokinetic properties of novel cPLA2α inhibitors with 1-(carboxyalkylpyrrolyl)-3-aryloxypropan-2-one structure

Synthesis, activity, metabolic stability and cell permeability of new cytosolic phospholipase A2α inhibitors with 1-indolyl-3-phenoxypropan-2-one structure

HPLC fluorescence assay for measuring the activity of NAPE-PLD and the action of inhibitors affecting this enzyme

Metabolism of sumatriptan revisited

Synthesis, activity and metabolic stability of propan-2-one substituted tetrazolylalkanoic acids as dual inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase

ω-(5-Phenyl-2H-tetrazol-2-yl)alkyl-substituted glycine amides and related compounds as inhibitors of the amine oxidase vascular adhesion protein-1 (VAP-1)

ω‐(5‐Phenyl‐2H‐tetrazol‐2‐yl)alkyl‐substituted hydrazides and related compounds as inhibitors of amine oxidase copper containing 3 (AOC3)

N-Substituted 4-sulfamoylbenzoic acid derivatives as inhibitors of cytosolic phospholipase A2α

Hexafluoroisopropyl Carbamates as Selective MAGL and Dual MAGL/FAAH Inhibitors: Biochemical and Physicochemical Properties

Aryl N-[ω-(6-Fluoroindol-1-yl)alkyl]carbamates as Inhibitors of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and Butyrylcholinesterase: Structure–Activity Relationships and Hydrolytic Stability

Collaborators (2)

Christoph Arenz

Klaus Langer

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