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Mayson H. Alkhatib

Professor

Oman

Research Interests

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Professors in Pharmaceutical Chemistry

Articles (15)

Year:

2026

Year:

2026

Year:

2026

Year:

2025

Year:

2025

Introduction: The approach for drug delivery has impressively developed with the emergence of nanosuspension, particularly the targeted nanoemulsions (NEs). It can potentially improve the bioavailability of drugs, enhancing their therapeutic efficiency. This study aims to examine the potential role of NE as a delivery system for the combination of docetaxel (DTX), a microtubule-targeting agent, and thymoquinone (TQ) in the treatment of human ductal carcinoma cells T47D. Methods: NEs were synthesized by ultra-sonication and characterized physically by dynamic light scattering (DLS). A sulforhodamine B assay was performed to evaluate cytotoxicity, and a flow cytometry analysis for cell cycle, apoptosis, autophagy, and cancer stem cell evaluations. A quantitative polymerase chain reaction further assessed the epithelial-mesenchymal transition gene expirations of SNAIL-1, ZEB-1, and TWIST-1. Results: The optimal sizes of blank-NEs and NE-DTX+TQ were found at 117.3 ± 8 nm and 373 ± 6.8 nm, respectively. The synergistic effect of the NE-DTX+TQ formulation significantly inhibited the in vitro proliferation of T47D cells. It caused a significant increase in apoptosis, accompanied by the stimulation of autophagy. Moreover, this formulation arrested T47D cells at the G2/M phase, promoted the reduction of the breast cancer stem cell (BCSC) population, and repressed the expression of TWIST-1 and ZEB-1. Conclusion: Co-delivery of NE-DTX+TQ may probably inhibit the proliferation of T47D via the induction of apoptosis and autophagy pathways and impede the migration by reducing the BCSC population and downregulating TWIST-1 expression to decrease the epithelial-to-mesenchymal transition (EMT) of breast cancer cells. Therefore, the study suggests the NE-DTX+TQ formula as a potential approach to inhibit breast cancer growth and metastasis.

Year:

2023

Year:

2023

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2020

Collaborators (73)

Vikash Ranjan Keshri

Associate Professor

O.P. Jindal Global University

Mayson H. Alkhatib

Research Interests

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Articles (15)

Global Burden of Elevated LDL-C

Global, regional, and national burden of meningitis, its risk factors, and aetiologies, 1990–2023

Arthroscope-guided intra-articular injection of chitosan–hyaluronate gel mixture vs hyaluronic acid in the treatment of temporomandibular joint internal derangement: a randomized controlled clinical trial

Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Synthesis and evaluation of chitosan/essential oil nanoemulsion beads for water treatment

Growth and invasion inhibition of T47D ductal carcinoma cells by the association of docetaxel with a bioactive agent in neutral nanosuspension

ANTIMICROBIAL ACTIVITY OF CHITOSAN-VITAMIN E-NANOEMULSION

Incorporation of topotecan into sesame oil - Nanoemulsion potentiates its cytotoxic effect in cancer cells

Antitumour effects of a solid lipid nanoparticle loaded with gemcitabine and oxaliplatin on the viability, apoptosis, autophagy, and Hsp90 of ovarian cancer cells

Antitumor Activities of Co-loading Gemcitabine and Oxaliplatin into Oleic Acid-Based Solid Lipid Nanoparticle against Non-Small Cell Lung Cancer Cells

Inhibition of Colon Cancer Cells Proliferation and Invasion by Etoposide Loaded on Nano-Suspensions Containing Black Currant Seed and Evening Primrose Oils

Carvacrol effect on topotecan cytotoxicity in various human cancer cells in vitro

Doxorubicin supplemented with pravastatin in lipid nanoemulsion induces antineoplastic activity with limited hepatotoxicity and cardiotoxicity in tumor-bearing mice

Formulating etoposide in a nanoemulsion containing polyunsaturated fatty acids potentiates its anti-proliferation and anti-invasion activities against the ovarian cancer cells

Incorporation of docetaxel and thymoquinone in borage nanoemulsion potentiates their antineoplastic activity in breast cancer cells

Collaborators (73)

Vikash Ranjan Keshri

Muktar Ahmed

Konstantinos Kotsis

MoezAlIslam Faris

Akshaya Bhagavathula

Áurea Madureira-Carvalho

Peter William Stubbs

Benn Sartorius

Haosu Tang

Omer Subasi

Yusuf Saleem Khan

Davide Golinelli

Lucie Laflamme

Priyadarshini Bhattacharjee

Amr Amin

Ulric Abonie

Sandra Barteit

Hosam Alzahrani

Emeka W. Dumbili

Shankar Bakkannavar

Mario Virgilio Papa

Graeme Hankey

Quynh Xuan Nguyen Truong

Yasir Waheed

Ferrán Catalá-López

David B Anderson

Dauda Salihu

Luís R. Silva

Angelo Capodici

Rahman Shiri

Muhammad Shahzad Aslam

Mubarak Taiwo Mustapha

Xiaoqi Feng

Senbagam Duraisamy

John Ji

MICHAEL BELINGHERI

Apostolos Beloukas

Stefania Mondello

Hassan Abolhassani

Ellina Lytvyak

Mohammad Ali Moni

Sameh S. M. Soliman

Qazi Mohammad Sajid Jamal

Jack Cagney

Muhammad Chutiyami

ABEL JOSEPH

Oyelola ADEGBOYE

Amrita Parida

Om Prakash Kurmi

Zhongyang Guan

Jeffrey Pradeep Raj

Debasish Kar

Utsav Parekh

Sangeeta Saxena

Leo Stockfelt

Saba Tariq

Muhammad Umair Khan

Konstantinos Giannakis

Dr Tenaw Yimer Tiruye

Himanshu Khajuria