Megan Baldridge

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Associate Professor

Washington University in St. Louis

United States

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About

Megan Baldridge is an Associate Professor at Washington University in St Louis, USA. Her research focuses on the intersection of infectious diseases and microbiota, with recent articles examining topics such as the inflammatory responses to dietary antigens caused by early life infections, the impact of antibiotics on B cell populations, and the role of host factors in enhancing rotavirus vaccine production. Additionally, she investigates the relationship between chronic pain and alterations in intestinal microbiota, as well as employing innovative techniques like single-cell genomics to study the human intestinal microbiota.

Recent Grants

Grant: Close

Identifying phage-bacterial host interactions in IBD

Open Date: 2022-07-01

Close Date: 2025-06-30

Grant: Close

Unbiased identification of novel antiviral effectors against enteric viral pathogens using CRISPR screening

Open Date: 2020-11-01

Close Date: 2025-11-01

Grant: Close

Norovirus regulation via bacterial modulation of interferon-lambda

Open Date: 2019-03-01

Close Date: 2024-02-29

Grant: Close

Microbiota-dependent regulation of primitive hematopoieses

Open Date: 2018-11-07

Close Date: 2023-10-31

Grant: Close

Role of CD300 Family in Norovirus Tropism, Persistence, and Immunity

Open Date: 2017-05-22

Close Date: 2023-04-30

Articles (15)

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2021

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2021

Collaborators (6)

Katherine Y. King

Baylor College of Medicine

UNITED STATES

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Craig Wilen

Associate Professor

Yale University

UNITED STATES

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Yinxing Zhu

Washington University in St. Louis

UNITED STATES

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Jakob von Moltke

Washington University School of Medicine

UNITED STATES

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Lila Nolan

Washington University School of Medicine

UNITED STATES

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Andres Bendesky

Columbia University

UNITED STATES

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Megan Baldridge

Research Interests

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About

Recent Grants

Articles (15)

Antibiotic treatment limits survival of peripheral and bone marrow B cell populations

Early life infection with Cryptosporidium parvum induces inflammatory responses to dietary antigens

CRISPR/Cas9 screens identify key host factors that enhance rotavirus reverse genetics efficacy and vaccine production

Chronic pain and complex regional pain syndrome are associated with alterations to the intestinal microbiota in both humans and mice. An observational cross-sectional study

Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection

Age-associated features of norovirus infection analysed in mice

Genetic mapping reveals Pou2af2/ OCA-T1–dependent tuning of tuft cell differentiation and intestinal type 2 immunity

Modelling human immune responses using microbial exposures in rodents

Single-cell genomics for resolution of conserved bacterial genes and mobile genetic elements of the human intestinal microbiota using flow cytometry

Norovirus from the mouths of babes.

The bacterial microbiota regulates normal hematopoiesis via metabolite-induced type 1 interferon signaling

Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium.

Microbiota regulation of viral infections through interferon signaling.

Enteric virome negatively affects seroconversion following oral rotavirus vaccination in a longitudinally sampled cohort of Ghanaian infants.

Differential roles of interferons in innate responses to mucosal viral infections

Collaborators (6)

Katherine Y. King

Craig Wilen

Yinxing Zhu

Jakob von Moltke

Lila Nolan

Andres Bendesky

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