Melanie Foecking

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Lecturer

Royal College of Surgeons in Ireland

Ireland

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About

Melanie Foecking is a Lecturer at the Royal College of Surgeons in Ireland. Her research focuses on the intersection of nutritional interventions and mental health, particularly in schizophrenia spectrum disorders, as well as the role of biomarkers in the transition to psychosis. Recent articles explore various aspects of psychiatric conditions, including cannabis use, complement proteins, and inflammation in youth. She is dedicated to advancing the understanding of psychosis and its related clinical symptoms through innovative research methodologies.

Recent Grants

Grant: Close

‘Investigating the relationship between the Complement Pathway and outcomes in Psychosis; from Clinical High Risk to First Episode Psychosis’

Open Date: 2022-12-01

Close Date: 2025-11-01

Grant: Close

The identification of plasma protein markers of antipsychotic drug treatment response in first episode psychosis; a proteomic analysis of baseline plasma samples from the OPTiMiSE and PSYSCAN studies

Open Date: 2019-11-01

Close Date: 2022-10-01

Grant: Close

Biomarker discovery in psychosis: a longitudinal study of inflammatory cytokines and metabolome in the plasma of high risk subjects and subjects recently converted to psychosis.

Open Date: 2016-10-01

Close Date: 2019-09-01

Grant: Close

The first assessment of multiple histone modifications in brain; an opportunity to identify multiple disease- associated, therapeutically targetable post translational modifications using mass spectrometry.

Open Date: 2016-09-01

Close Date: 2017-08-01

Grant: Close

An Inflammatory Biomarker Study of Psychosis: a Longitudinal Study in an At Risk Population

Open Date: 2016-01-01

Close Date: 2020-05-01

Articles (19)

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2025

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2024

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2021

Collaborators (12)

Stanley Zammit

University of Bristol

UNITED KINGDOM

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david cotter

Royal College of Surgeons in Ireland

IRELAND

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Thomas Pollak

King’s College London

UNITED KINGDOM

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Philip McGuire

King’s College London

UNITED KINGDOM

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Paola Dazzan

King’s College London

UNITED KINGDOM

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Gerard Cagney

Lecturer

Dublin City University

IRELAND

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Colm Healy

University College Dublin

IRELAND

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John Paul Lyne

Associate Professor

Royal College of Surgeons in Ireland

IRELAND

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Vanessa Cropley

AUSTRALIA

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Rebekah Street

University of Melbourne

AUSTRALIA

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Alice Egerton

Reader in Neuropsychopharmacology

King’s College London

UNITED KINGDOM

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David Mongan

The Queen's University Belfast

UNITED KINGDOM

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Melanie Foecking

Research Interests

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About

Recent Grants

Articles (19)

Impact of nutritional interventions on quality of life in schizophrenia spectrum disorders: a scoping review

Proteomic Biomarkers for the Prediction of Transition to Psychosis in Individuals at Clinical High Risk: A Multi-cohort Model Development Study

Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms

Cannabis use in youth is associated with chronic inflammation

Plasma levels of matrix metalloproteinases in early psychosis, anxiety and depression: Evidence from the ALSPAC cohort

Complement C4, C4A and C4a - What they do and how they differ.

Plasma complement and coagulation proteins as prognostic factors of negative symptoms: An analysis of the NAPLS 2 and 3 studies

Sample processing time but not storage time affects complement activation markers C4a, C4d, C3a, iC3b, Bb, C5a, and sC5b-9 levels in EDTA-plasma of individuals at clinical high-risk for psychosis

Associations between plasma inflammatory markers and psychotic disorder, depressive disorder and generalised anxiety disorder in early adulthood

Association of Complement and Coagulation Pathway Proteins With Treatment Response in First-Episode Psychosis: A Longitudinal Analysis of the OPTiMiSE Clinical Trial

Complement proteins are elevated in blood serum but not CSF in clinical high-risk and antipsychotic-naïve first-episode psychosis.

Prognostic models predicting transition to psychotic disorder using blood-based biomarkers: a systematic review and critical appraisal

Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis.

Transdiagnostic inflammatory subgroups among psychiatric disorders and their relevance to role functioning: a nested case-control study of the ALSPAC cohort

Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis

Machine learning based prediction and the influence of complement – Coagulation pathway proteins on clinical outcome: Results from the NEURAPRO trial

Omega-3 fatty acid in ultra-high-risk psychosis: A systematic review based on functional outcome

The association of plasma inflammatory markers with omega-3 fatty acids and their mediating role in psychotic symptoms and functioning: An analysis of the NEURAPRO clinical trial

Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress

Collaborators (12)

Stanley Zammit

david cotter

Thomas Pollak

Philip McGuire

Paola Dazzan

Gerard Cagney

Colm Healy

John Paul Lyne

Vanessa Cropley

Rebekah Street

Alice Egerton

David Mongan

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