Melissa Lechner

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Asst. Professor of Medicine, Onco-Endocrinology Program

David Geffen School of Medicine at UCLA

United States

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About

Melissa Lechner is an Assistant Professor of Medicine in the Onco-Endocrinology Program at the David Geffen School of Medicine at UCLA. Her research focuses on the interplay between cancer treatment and thyroid function, particularly in the context of immunotherapy and its effects on endocrine health. Recent publications include investigations into immune-related adverse events in cancer patients and clinical outcomes in thyroid carcinoma related to genetic variants.

Recent Grants

Grant: Close

Mechanisms of Thyroid Autoimmunity in Checkpoint Immunotherapy

Open Date: 2021-09-15

Close Date: 2026-07-30

Grant: Close

Targets for Prevention of Autoimmune Toxicities from Checkpoint Immunotherapy

Open Date: 2021-07-01

Close Date: 2023-06-01

Grant: Close

Role of Recent Thymic T Cells in Immune Checkpoint Inhibitor Thyroiditis

Open Date: 2020-07-01

Close Date: 2022-06-01

Articles (17)

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2025

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2022

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2020

Collaborators (9)

Maureen A. Su

University of California

UNITED STATES

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Noah Wald-Dickler

Hospital Epidemiologist & Chief of Infectious Disease

UCLA Medical Center

UNITED STATES

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Gregory A Brent

David Geffen School of Medicine at UCLA

UNITED STATES

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Irene Kang

Assistant Professor of Clinical Medicine

University of Southern California

UNITED STATES

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Nikhita Kathuria-Prakash

University of California, Los Angeles

UNITED STATES

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Willy Hugo

Assistant Professor

David Geffen School of Medicine at UCLA

UNITED STATES

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Trevor Angell

University of Southern California

UNITED STATES

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Lauren Antrim

City Of Hope National Medical Center

UNITED STATES

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Jason Whitmire

Professor

University of North Carolina at Chapel Hill

UNITED STATES

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Melissa Lechner

Research Interests

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About

Recent Grants

Articles (17)

Efficacy and immune-related adverse events of pembrolizumab with bone-modifying agents in female patients with breast cancer

Medullary Thyroid Carcinoma and Clinical Outcomes in Heterozygous Carriers of the RET K666N Germline Pathogenic Variant

A pathologically expanded, clonal lineage of IL-21–producing CD4+ T cells drives inflammatory neuropathy

The Effect of Apalutamide on Thyroid Function in Prostate Cancer Patients

A New Twist on a Classic: Enhancing Radioiodine Uptake in Advanced Thyroid Cancer

The Combined Effect of Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors on Thyroid Function

Risk of severe immune-related adverse events in cancer patients with pre-existing autoimmunity receiving immune checkpoint inhibitor therapy

Clonally expanded, thyrotoxic effector CD8<sup>+</sup> T cells driven by IL-21 contribute to checkpoint inhibitor thyroiditis

Inhibition of IL-17A Protects against Thyroid Immune-Related Adverse Events while Preserving Checkpoint Inhibitor Antitumor Efficacy

Pathogenic TNF-α drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity

Factors Associated With Hospitalization Among Breast Cancer Patients With COVID-19: A Diverse Multi-Center Los Angeles Cohort Study

Fireside Chat on “Optimal Thyroid Hormone Replacement Dose in Immune Checkpoint Inhibitor-Associated Hypothyroidism Is Distinct from Hashimoto's Thyroiditis”

Inhibition of the IL-17A axis Protects against Immune-related Adverse Events while Supporting Checkpoint Inhibitor Anti-tumor Efficacy

Sex Differences in Immunity

Frequency of Thyroid Hormone Replacement After Lobectomy for Differentiated Thyroid Cancer.

COVID-19 Outcomes of Patients With Differentiated Thyroid Cancer: A Multicenter Los Angeles Cohort Study.

Changes in Stage Distribution and Disease-Specific Survival in Differentiated Thyroid Cancer with Transition to American Joint Committee on Cancer 8th Edition: A Systematic Review and Meta-Analysis.

Collaborators (9)

Maureen A. Su

Noah Wald-Dickler

Gregory A Brent

Irene Kang

Nikhita Kathuria-Prakash

Willy Hugo

Trevor Angell

Lauren Antrim

Jason Whitmire

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