Michał Otręba

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Professor (Assistant)

Medical University of Silesia, Faculty of Pharmaceutical Sciences in Sosnowiec

Poland

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About

Professor Michał Otręba serves as an Assistant Professor at the Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Poland. His research primarily focuses on the cytotoxicity of antipsychotic medications in cancer therapy, particularly the effects of phenothiazine derivatives on glioblastoma and astrocytes. Additionally, he explores the potential health benefits of bee products and their applications in the treatment of viral infections.

Recent Grants

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Anticancer activity of selected phenothiazine derivatives against glioblastoma and normal human astrocytes

Open Date: 2021-12-01

Close Date: 2024-12-01

Grant: Close

Effect of selected phenothiazine derivatives on antioxidant status and apoptosis in glioblastoma cells

Open Date: 2019-09-01

Close Date: 2021-12-01

Grant: Close

Evaluation of antitumour activity of phenothiazine derivatives

Open Date: 2016-06-01

Close Date: 2019-10-01

Grant: Close

Changes in antioxidant status of melanocytes grown in the presence of selected drugs

Open Date: 2015-05-01

Close Date: 2017-10-01

Grant: Close

Impact of phenothiazine derivatives on biochemical processes in normal human melanocytes

Open Date: 2014-05-01

Close Date: 2017-12-01

Articles (18)

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2025

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2025

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2025

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2024

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2020

Collaborators (9)

Anna Rzepecka‐Stojko

POLAND

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Michał Górecki

Medical University of Silesia, Faculty of Pharmaceutical Sciences in Sosnowiec

POLAND

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Leon Kosmider

Assistant Professor

Medical University of Silesia

POLAND

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Anna Kleczka

Lecturer

Medical University of Silesia

POLAND

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Jerzy Stojko

Medical University of Silesia

POLAND

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Paweł Olczyk

Medical University of Silesia

POLAND

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Łukasz Marek

assistant professor

Medical University of Silesia

POLAND

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Morten Grøtli

Professor

University of Gothenburg

SWEDEN

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Agata Kabała-Dzik

Associate Professor

Medical University of Silesia

POLAND

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Michał Otręba

Research Interests

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Recent Grants

Articles (18)

Antioxidant Activity of Prochlorperazine Dimaleate

Comparative cytotoxicity of perphenazine on different human glioblastoma cells

Bee products as alternatives in the treatment of viral infections

Effect of perphenazine and prochlorperazine on viability of human astrocytes

Targeting autophagy by antipsychotic phenothiazines: potential drug repurposing for cancer therapy.

The role of phenothiazine derivatives in autophagy regulation: A systematic review

Special Issue on Propolis and Other Bee Products: Beneficial Effects on Health and Processing Technology

Phenothiazine derivatives and their impact on the necroptosis and necrosis processes. A review.

Phenothiazine derivatives and their impact on the necroptosis and necrosis processes. A review

Propolis as Natural Product in the Oral Cavity Bacterial Infections Treatment: A Systematic Review

Comparison of the Antioxidant Activity of Propolis Samples from Different Geographical Regions

Perphenazine and prochlorperazine decrease glioblastoma U‑87 MG cell migration and invasion: Analysis of the ABCB1 and ABCG2 transporters, E‑cadherin, α‑tubulin and integrins (α3, α5, and β1) levels

A Small Molecule Targeting Human MEK1/2 Enhances ERK and p38 Phosphorylation under Oxidative Stress or with Phenothiazines.

Polyphenols’ Cardioprotective Potential: Review of Rat Fibroblasts as Well as Rat and Human Cardiomyocyte Cell Lines Research

In vitro anticancer activity of fluphenazine, perphenazine and prochlorperazine. A review

Bee Venom, Honey, and Royal Jelly in the Treatment of Bacterial Infections of the Oral Cavity: A Review

In vitroanticancer activity of fluphenazine, perphenazine and prochlorperazine. A review

Cardioprotective Activity of Selected Polyphenols Based on Epithelial and Aortic Cell Lines. A Review

Collaborators (9)

Anna Rzepecka‐Stojko

Michał Górecki

Leon Kosmider

Anna Kleczka

Jerzy Stojko

Paweł Olczyk

Łukasz Marek

Morten Grøtli

Agata Kabała-Dzik

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