Michael L. Nielsen

Nielsen Laboratory at Aarhus University is seeking a postdoctoral researcher to help develop next-generation mass spectrometry and proteomics technologies. The position is based in the Department of Molecular Biology and Genetics, where the group is building a growing research programme around advanced analytical methods for studying regulatory protein states, post-translational modifications, and cellular signalling. The successful candidate will join an environment that combines state-of-the-art mass spectrometry with quantitative proteomics, analytical method development, peptide and protein chemistry, and PTM biology. The project is strongly technology-driven: the postdoc will work on creating and refining analytical workflows that improve sensitivity, robustness, reproducibility, and throughput in modern proteomics. Research directions mentioned in the advert include advanced LC-MS/MS acquisition strategies, chromatographic optimisation, automated sample preparation, quantitative PTM proteomics, and new approaches for studying protein regulation. The role offers considerable scientific freedom, making it well suited to a researcher who wants to pursue innovative ideas and translate method development into high-impact publications. The position also carries a group-building dimension. As an early member of a newly established laboratory at Aarhus University, the postdoc will contribute to shaping experimental capabilities, research directions, and collaborative projects while working in a broad interdisciplinary setting that connects proteomics with molecular biology, analytical chemistry, genome stability, structural biology, and enzymology. The lab describes itself as having more than 15 years of internationally recognised research in regulatory proteomics, ADP-ribosylation biology, and mass spectrometry-based technology development, now expanded into a new Aarhus University setting with strong infrastructure and international links.

Two postdoctoral positions are open at Aarhus University in the Department of Molecular Biology and Genetics , within the Nielsen Laboratory . The positions sit at the interface of proteomics , mass spectrometry , post-translational modification (PTM) biology , genome stability , DNA repair , and technology development . Postdoc #1 focuses on mechanisms regulating PARP1 function, ADP-ribosylation signalling, genome maintenance, DNA damage responses, and responses to PARP inhibitor therapy . This project is funded by the Danish Cancer Society . Postdoc #2 focuses on developing next-generation proteomics technologies, including quantitative PTM analysis , DIA workflows , laboratory automation, scalable proteomics workflows, and innovative LC-MS/MS methodologies. The lab combines quantitative proteomics, mechanistic cell biology, and PTM biology to study how regulatory protein states control cellular function. Applicants with backgrounds in proteomics , mass spectrometry , PTM biology , genome stability , computational biology , molecular biology, biochemistry, or cell biology are encouraged to apply. The positions are fully funded , initially for two years , with the possibility of extension. The expected start date is 1 October 2026 or soon thereafter. The application deadline is 10 August 2026 . Applicants should submit the application in English and include a CV, degree certificate, complete publication list, statement of future research plans, and information about research activities and teaching experience if applicable. In the cover letter, applicants should clearly state whether they are applying for position #1, #2, or both, and explain how their expertise fits the scientific goals of the selected project(s). This is a strong opportunity for researchers interested in regulatory proteomics , ADP-ribosylation , DNA repair , cancer biology , and proteomics technology development in a highly collaborative and internationally connected environment.