Michael Latham

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Associate Professor

University of Minnesota

United States

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About

Michael Latham is an Associate Professor at the University of Minnesota, USA. His research primarily focuses on molecular recognition, structural plasticity in nucleic acid complexes, and the biochemical characterization of proteins related to DNA repair and RNA processing. Recent publications explore topics such as the binding mechanisms of DNA and RNA in relation to protein structures, as well as the dynamic conformations of multi-domain protein complexes.

Recent Grants

Grant: Close

Structural biology studies of a large DNA repair complex

Open Date: 2018-09-01

Close Date: 2023-08-01

Grant: Close

Uncovering allosteric coupling in a DNA damage repair complex with methyl-based NMR spectroscopy

Open Date: 2018-06-01

Close Date: 2021-05-01

Grant: Close

Structural and Functional Characterization of the DNA Double Strand Break Processing Complex of Mre11-Rad50

Open Date: 2018-02-21

Close Date:

Grant: Close

Methyl-based NMR Investigation of a DNA Double Strand Break Repair Complex

Open Date: 2015-06-01

Close Date: 2018-05-01

Articles (14)

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2025

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2023

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2023

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2022

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2022

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2021

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2021

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2020

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2020

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2020

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2020

Collaborators (2)

Bryan Sutton

Professor

Texas Tech University Health Sciences Center

UNITED STATES

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Elliott J. Stollar

UNITED STATES

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Michael Latham

Research Interests

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About

Recent Grants

Articles (14)

Molecular recognition and structural plasticity in amyloid–nucleic acid complexes

Saccharomyces cerevisiae Xrs2 Binds DNA Through Its FHA Domain

Dynamic conformations of the P. furiosus MR-DNA complex link Mre11 nuclease activity to DNA-stimulated Rad50 ATP hydrolysis

Human CSTF2 RNA Recognition Motif Domain Binds to a U-Rich RNA Sequence through a Multistep Binding Process

How a highly acidic SH3 domain folds in the absence of its charged peptide target

Three segment ligation of a 104 kDa multi-domain protein by SrtA and OaAEP1

Structural features of Dnase1L3 responsible for serum antigen clearance

Electrostatic Interactions between CSTF2 and pre-mRNA Drive Cleavage and Polyadenylation

The dynamic nature of the Mre11-Rad50 DNA break repair complex

Biochemical and structural characterization of analogs of MRE11 breast cancer-associated mutant F237C

Maturation of the functional mouse CRES amyloid from globular form

A missense mutation in the CSTF2 gene that impairs the function of the RNA recognition motif and causes defects in 3′ end processing is associated with intellectual disability in humans

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex

Adjacent mutations in the archaeal Rad50 ABC ATPase D-loop disrupt allosteric regulation of ATP hydrolysis through different mechanisms

Collaborators (2)

Bryan Sutton

Elliott J. Stollar

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