Michael S. Cohen

Oregon Health & Science University

United States

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Articles (4)

Year:

2023

We introduce the first cysteine-targeted covalent PARP inhibitor (DB008), equipped with a clickable alkyne for enhanced PARP family-wide selectivity, and discovered that inhibition of PARP16 prevents auto-aggregation under nutrient stress.

Year:

2022

Year:

2021

Year:

2021

Collaborators (1)

Terence Ryan

Assistant Professor

University of Florida

UNITED STATES

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Michael S. Cohen

Research Interests

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Articles (4)

Immunomodulatory roles of PARPs: Shaping the tumor microenvironment, one ADP-ribose at a time.

Structure-guided design and characterization of a clickable, covalent PARP16 inhibitor

Mitochondrial Permeability Transition Causes Mitochondrial Reactive Oxygen Species- and Caspase 3-Dependent Atrophy of Single Adult Mouse Skeletal Muscle Fibers

Characterization of PARP6 Function in Knockout Mice and Patients with Developmental Delay

Collaborators (1)

Terence Ryan

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