Michal Hocek

Professor

Charles University

Czech Republic

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About

Professor Michal Hocek is a faculty member at Charles University in the Czech Republic. His research focuses on enzymatic synthesis and modification of nucleic acids, including base-modified DNA and RNA, as evidenced by his recent publications. His work explores applications such as bioconjugation, cross-linking, and the effects of modified nucleotides on transcription processes.

Articles (27)

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2025

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2023

Collaborators (3)

Ugnė Šinkevičiūtė

Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

CZECH REPUBLIC

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Miguel Riopedre Fernandez

Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

CZECH REPUBLIC

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Oliver Šimončík

Masaryk Memorial Cancer Institute

CZECH REPUBLIC

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Michal Hocek

Research Interests

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About

Articles (27)

Versatile Enzymatic Approach for Truncation, Labeling, and Mutation of Nucleobase‐Modified Aptamers Demonstrated on Indole‐Modified β‐Conglutin Aptamer

Milligram‐Scale Enzymatic Synthesis of Base‐Modified DNA through Primer Extension: Polymerase Synthesis and NMR Structures of DNA Containing Phenyl‐Substituted Nucleobases

Polymerase Synthesis of Hypermodified DNA Displaying a Combination of Thiol, Hydroxyl, Carboxylate, and Imidazole Functional Groups in the Major Groove

Synthesis of 2‐Substituted Adenosine Triphosphate Derivatives and their use in Enzymatic Synthesis and Postsynthetic Labelling of RNA

Zwitterionic DNA: enzymatic synthesis of hypermodified DNA bearing four different cationic substituents at all four nucleobases

Synthesis and Biological Activity of 2,6‐Disubstituted 7‐Deazapurine Ribonucleosides

Enzymatic synthesis of reactive RNA probes containing squaramate-linked cytidine or adenosine for bioconjugations and cross-linking with lysine-containing peptides and proteins

Using environment-sensitive tetramethylated thiophene-BODIPY fluorophores in DNA probes for studying effector-induced conformational changes of protein–DNA complexes

ABNOH‐Linked Nucleotides and DNA for Bioconjugation and Cross‐linking with Tryptophan‐Containing Peptides and Proteins

Glyco‐DNA: Enzymatic Synthesis of Base‐Modified and Hypermodified DNA Displaying up to Four Different Monosaccharide Units in the Major Groove

Addendum: Expedient production of site specifically nucleobase-labelled or hypermodified RNA with engineered thermophilic DNA polymerases

Synthesis and Biological Profiling of Quinolino-Fused 7-Deazapurine Nucleosides

Expedient production of site specifically nucleobase-labelled or hypermodified RNA with engineered thermophilic DNA polymerases

Bacteriophage-related epigenetic natural and non-natural pyrimidine nucleotides and their influence on transcription with T7 RNA polymerase

Real‐time Imaging of Nascent DNA in Live Cells by Monitoring the Fluorescence Lifetime of DNA‐Incorporated Thiazole Orange‐Modified Nucleotides

Real‐time Imaging of Nascent DNA in Live Cells by Monitoring the Fluorescence Lifetime of DNA‐Incorporated Thiazole Orange‐Modified Nucleotides

Normalized Multipotential Redox Coding of DNA Bases for Determination of Total Nucleotide Composition

The selection of a hydrophobic 7-phenylbutyl-7-deazaadenine-modified DNA aptamer with high binding affinity for the Heat Shock Protein 70

trans-Cyclooctene- and Bicyclononyne-Linked Nucleotides for Click Modification of DNA with Fluorogenic Tetrazines and Live Cell Metabolic Labeling and Imaging

Chloroacetamide‐Modified Nucleotide and RNA for Bioconjugations and Cross‐Linking with RNA‐Binding Proteins

Chloroacetamide-Modified Nucleotide and RNA for Bioconjugations and Cross-Linking with RNA-Binding Proteins

Chloroacetamide‐Modified Nucleotide and RNA for Bioconjugations and Cross‐Linking with RNA‐Binding Proteins

Nucleotides Bearing Red Viscosity-Sensitive Dimethoxy-Bodipy Fluorophore for Enzymatic Incorporation and DNA Labeling

Nucleotides Bearing Red Viscosity-Sensitive Dimethoxy-Bodipy Fluorophore for Enzymatic Incorporation and DNA Labeling

Superanionic DNA: enzymatic synthesis of hypermodified DNA bearing four different anionic substituents at all four nucleobases

Synthesis and Biological Profiling of Benzofuro‐Fused 7‐Deazapurine Nucleosides

Arylethynyl- or Alkynyl-Linked Pyrimidine and 7-Deazapurine 2′-Deoxyribonucleoside 3′-Phosphoramidites for Chemical Synthesis of Hypermodified Hydrophobic Oligonucleotides

Collaborators (3)

Ugnė Šinkevičiūtė

Miguel Riopedre Fernandez

Oliver Šimončík

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