Min-Xin Guan

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University of Toronto

Canada

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About

Professor Min-Xin Guan is a faculty member at the University of Toronto. His research primarily focuses on mitochondrial genetics and cellular homeostasis, exploring topics such as mitochondrial tRNA processing defects and their implications in human diseases like Leber's hereditary optic neuropathy. Recent contributions include investigations into the effects of specific mitochondrial mutations on vision and hearing, as well as developing predictive tools for tissue-specific splicing related to mitochondrial dysfunction.

Recent Grants

Grant: Close

Nuclear modifier genes for maternally inherited deafness

Open Date: 2007-07-01

Close Date: 2011-06-30

Grant: Close

Human Genetics

Open Date: 2007-01-01

Close Date: 2009-12-31

Grant: Close

Mitochondrial genome correlation with Leber's disease

Open Date: 2004-01-01

Close Date: 2008-12-31

Grant: Close

Molecular Mechanism of Aminoglycoside Ototoxicity

Open Date: 2002-09-15

Close Date: 2008-08-31

Grant: Close

Genetic Correction of Maternally Inherited Diseases

Open Date: 2002-08-01

Close Date: 2006-07-31

Articles (20)

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2025

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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Min-Xin Guan

Research Interests

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About

Recent Grants

Articles (20)

Mitochondrial tRNA processing defects reprogram mitochondrial and cellular homeostasis

Vitamin A treatment restores vision failures arising from Leber’s hereditary optic neuropathy–linked mtDNA mutation

Deafness-associated mitochondrial 12S rRNA mutation reshapes mitochondrial and cellular homeostasis

Mutation of CRYAB encoding a conserved mitochondrial chaperone and antiapoptotic protein causes hereditary optic atrophy

Deafness-associated tRNAPhe mutation impaired mitochondrial and cellular integrity

Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis

Mitochondrial tRNA<sup>Glu</sup> 14693A > G Mutation, an “Enhancer” to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy

SpliceTransformer predicts tissue-specific splicing linked to human diseases

Defective biogenesis of human mitochondrial ribosomes causes sensorineural deafness

Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation

Nuclear modifier YARS2 allele correction restored retinal ganglion cells-specific deficiencies in Leber’s hereditary optic neuropathy

Abnormal morphology and function in retinal ganglion cells derived from patients-specific iPSCs generated from individuals with Leber’s hereditary optic neuropathy

Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations

Leber’s hereditary optic neuropathy-associated ND6 14484T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy

Genetic correction of TRMU allele restored the mitochondrial dysfunction-induced deficiencies in iPSCs-derived hair cells of hearing-impaired patients

A deafness-associated mitochondrial DNA mutation caused pleiotropic effects on DNA replication and tRNA metabolism

Mitochondrial tRNA variants in 811 Chinese probands with Leber’s hereditary optic neuropathy

Investigating the Broad Matrix-Gate Network in the Mitochondrial ADP/ATP Carrier through Molecular Dynamics Simulations

FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism

Tissue-specific expression atlas of murine mitochondrial tRNAs

Make your next move.

Min-Xin Guan

Research Interests

Explore related searches

About

Recent Grants

Articles (20)

Mitochondrial tRNA processing defects reprogram mitochondrial and cellular homeostasis

Vitamin A treatment restores vision failures arising from Leber’s hereditary optic neuropathy–linked mtDNA mutation

Deafness-associated mitochondrial 12S rRNA mutation reshapes mitochondrial and cellular homeostasis

Mutation of CRYAB encoding a conserved mitochondrial chaperone and antiapoptotic protein causes hereditary optic atrophy

Deafness-associated tRNAPhe mutation impaired mitochondrial and cellular integrity

Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis

Mitochondrial tRNA<sup>Glu</sup> 14693A &gt; G Mutation, an “Enhancer” to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy

SpliceTransformer predicts tissue-specific splicing linked to human diseases

Defective biogenesis of human mitochondrial ribosomes causes sensorineural deafness

Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation

Nuclear modifier YARS2 allele correction restored retinal ganglion cells-specific deficiencies in Leber’s hereditary optic neuropathy

Abnormal morphology and function in retinal ganglion cells derived from patients-specific iPSCs generated from individuals with Leber’s hereditary optic neuropathy

Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations

Leber’s hereditary optic neuropathy-associated ND6 14484T &gt; C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy

Genetic correction of TRMU allele restored the mitochondrial dysfunction-induced deficiencies in iPSCs-derived hair cells of hearing-impaired patients

A deafness-associated mitochondrial DNA mutation caused pleiotropic effects on DNA replication and tRNA metabolism

Mitochondrial tRNA variants in 811 Chinese probands with Leber’s hereditary optic neuropathy

Investigating the Broad Matrix-Gate Network in the Mitochondrial ADP/ATP Carrier through Molecular Dynamics Simulations

FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism

Tissue-specific expression atlas of murine mitochondrial tRNAs

Make your next move.

Mitochondrial tRNA<sup>Glu</sup> 14693A > G Mutation, an “Enhancer” to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy

Leber’s hereditary optic neuropathy-associated ND6 14484T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy