Moanaro Biswas

Assistant Professor

Indiana State University

United States

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Moanaro Biswas is an Assistant Professor at Indiana University, USA. His research primarily focuses on immunology, specifically investigating regulatory T cells, gene therapy, and immune modulation in the context of hemophilia A. Recent publications include studies on-engineered immunocytokines and their effects on immune responses, as well as novel strategies for optimizing AAV gene therapy through immune suppression protocols.

Articles (17)

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2025

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2020

Collaborators (4)

Lindsey George

Assistant Professor (Tenure Track)

University of Pennsylvania Perelman School of Medicine

UNITED STATES

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Roland W. Herzog

Indiana State University

UNITED STATES

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Shannon Meeks

Professor of Pediatrics

Emory University

UNITED STATES

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Michelle M. Martinez-Irizarry

Assistant Research Professor

Indiana University Bloomington

UNITED STATES

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Moanaro Biswas

Research Interests

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Articles (17)

An engineered Treg selective immunocytokine induces sustained immune modulation in a preclinical model of hemophilia A

B cell focused transient immune suppression protocol for efficient AAV readministration to the liver

Chopping down antibodies for a good cause

Role of FoxP3<sup>+</sup> Regulatory T Cells in Modulating Immune Responses to Adeno-Associated Virus Gene Therapy

TLR9-independent CD8<sup>+</sup> T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling

Characterization of a Bioengineered AAV3B Capsid Variant with Enhanced Hepatocyte Tropism and Immune Evasion

Innovation and clinical progress in oral tolerance

Suppression of anti-drug antibody formation against coagulation factor VIII by oral delivery of anti-CD3 monoclonal antibody in hemophilia A mice

Factor VIII trafficking to CD4+ T cells shapes its immunogenicity and requires several types of antigen-presenting cells.

Distinct functions and transcriptional signatures in orally induced regulatory T cell populations

Oral tolerance to prevent anti-drug antibody formation in protein replacement therapies

B cell–activating factor modulates the factor VIII immune response in hemophilia A

Role of orally induced regulatory T cells in immunotherapy and tolerance.

Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity.

Regulatory T cell therapy: Current and future design perspectives.

Neutralizing the Neutralizers in AAV Gene Therapy.

B Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin.

Collaborators (4)

Lindsey George

Roland W. Herzog

Shannon Meeks

Michelle M. Martinez-Irizarry

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