Mohsin Jafri

Professor

George Mason University

United States

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Mohsin Jafri is a Professor at George Mason University in the United States. His research areas encompass inflammatory signaling pathways in ulcerative colitis, drug resistance in colorectal cancer, and computational insights into calcium signaling. Additionally, he investigates mitochondrial dynamics, Alzheimer’s disease signaling, and cardiac arrhythmogenic activities. His work also includes the application of machine learning and text mining to understand genetic variants associated with various diseases.

Articles (21)

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2025

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2022

Collaborators (1)

W. Jonathan Lederer

UNITED STATES

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Mohsin Jafri

Research Interests

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Articles (21)

Transcriptional profiling identification of inflammatory signaling pathways in ulcerative colitis

Combining Molecular Dynamics and Machine Learning to Predict Drug Resistance Causing Variants of BRAF in Colorectal Cancer

Editorial on Special Issue: Computational Insights into Calcium Signaling

How the Topology of the Mitochondrial Inner Membrane Modulates ATP Production

Structural Analysis of Amylin and Amyloid β Peptide Signaling in Alzheimer’s Disease

Text Mining to Understand Disease-Causing Gene Variants

Boolean Modeling of Biological Network Applied to Protein–Protein Interaction Network of Autism Patients

Evaluating Ovarian Cancer Chemotherapy Response Using Gene Expression Data and Machine Learning

Gain-of-Function and Loss-of-Function Mutations in the RyR2-Expressing Gene Are Responsible for the CPVT1-Related Arrhythmogenic Activities in the Heart

Using a Failing Human Ventricular Cardiomyocyte Model to Re-Evaluate Ca2+ Cycling, Voltage Dependence, and Spark Characteristics

Local Control Model of a Human Ventricular Myocyte: An Exploration of Frequency-Dependent Changes and Calcium Sparks

Structural Analysis of Mitochondria in Cardiomyocytes: Insights into Bioenergetics and Membrane Remodeling

Protein–Protein Interaction Network Extraction Using Text Mining Methods Adds Insight into Autism Spectrum Disorder

Understanding Calmodulin Variants Affecting Calcium-Dependent Inactivation of L-Type Calcium Channels through Whole-Cell Simulation of the Cardiac Ventricular Myocyte

Pacing Dynamics Determines the Arrhythmogenic Mechanism of the CPVT2-Causing CASQ2G112+5X Mutation in a Guinea Pig Ventricular Myocyte Computational Model

Molecular Dynamics Simulations to Decipher the Role of Phosphorylation of SARS-CoV-2 Nonstructural Proteins (nsps) in Viral Replication

The Role of Ca2+ Sparks in Force Frequency Relationships in Guinea Pig Ventricular Myocytes

Critical Requirements for the Initiation of a Cardiac Arrhythmia in Rat Ventricle: How Many Myocytes?

Understanding the Dynamics of the Transient and Permanent Opening Events of the Mitochondrial Permeability Transition Pore with a Novel Stochastic Model

Active site prediction of phosphorylated SARS-CoV-2 N-Protein using molecular simulation

Optimizing peptide inhibitors of SARS-Cov-2 nsp10/nsp16 methyltransferase predicted through molecular simulation and machine learning

Collaborators (1)

W. Jonathan Lederer

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