Molly M. Fox

Pica, the urge to consume items generally not considered food, such as dirt, raw starch, and ice, are particularly common among pregnant women. However, the biology of pica in pregnancy is not well understood. Therefore, this study aimed to assess how pica relates to endocrine stress and immune biomarkers in a cohort of pregnant Latina women in Southern California. Thirty‐four women completed a structured pica questionnaire. Maternal urinary cortisol and plasma cytokine levels were measured between 21 and 31 weeks' gestation. Associations between pica during pregnancy and biomarkers were assessed using linear regression models adjusting for gestational age. Twelve (35.3%) of the pregnant women reported pica (geophagy and amylophagy) during pregnancy. In multivariate models, those who engaged in pica had higher levels of cortisol ( β : 0.37, 95% CI: 0.01, 0.073) and lower levels of IL‐1β ( β : −0.06, 95% CI: −0.11, −0.02), IL‐8 ( β : −0.30, 95% CI: −0.56, −0.05), IL‐21 ( β : −0.35, 95% CI: −0.63, −0.08), and type‐1 inflammation composite ( β : −0.29, 95% CI: −0.44, −0.14) than women who did not engage in pica. These results suggest that biological stress and immune response differ for women with pica compared to those without. This study suggests novel physiological covariates of pica during pregnancy. Further research is needed to better understand the mechanisms and temporality underlying the observed associations between pica and endocrine and immune biomarkers.