Motoko Unoki

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Associate Professor

University of Tokyo

Japan

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About

Motoko Unoki is an Associate Professor at the University of Tokyo, Japan. Her research spans several areas including epigenetics, immunology, and genetic regulatory mechanisms, as evidenced by her recent articles on isoform expression in human B cells and the genetic basis of coloration in tortoiseshell cats. Additionally, she explores the role of the UHRF1 protein in cellular architecture and various syndromes linked to immunodeficiency and developmental anomalies.

Recent Grants

Grant: Close

Mechanisms underlying maintenance of genome integrity by DNA methylation

Open Date: 2019-06-28

Close Date: 2024-03-31

Grant: Close

Molecular pathogenesis of ICF syndrome

Open Date: 2018-04-01

Close Date: 2021-03-31

Grant: Close

Role of UHRF1 during oogenesis and early embryogenesis

Open Date: 2015-04-01

Close Date: 2018-03-31

Grant: Close

ICF syndrome and the molecular network regulating the human epigenome

Open Date: 2014-04-01

Close Date: 2017-03-31

Grant: Close

Dynamics and regulation of genomic imprinting and DNA methylation

Open Date: 2013-06-28

Close Date: 2018-03-31

Articles (18)

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Haruhiko Koseki

Chiba University

JAPAN

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Kyohei Arita

Professor

Yokohama National University

JAPAN

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Motoko Unoki

Research Interests

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About

Recent Grants

Articles (18)

Long-read sequencing reveals novel isoform-specific eQTLs and regulatory mechanisms of isoform expression in human B cells

A deletion at the X-linked ARHGAP36 gene locus is associated with the orange coloration of tortoiseshell and calico cats

Low awareness but high willingness to engage in science communication: a cross-disciplinary survey study in a Japanese University

The maternal protein NLRP5 stabilizes UHRF1 in the cytoplasm: implication for the pathogenesis of multilocus imprinting disturbance

Exploring the intersection of epigenetics, DNA repair, and immunology from studies of ICF syndrome, an inborn error of immunity

Inhibitory effects of extracts from <i>Eucalyptus gunnii</i> on α-synuclein amyloid fibrils

Long-read sequencing reveals the complex structure of extra dic(21;21) chromosome and its biological effects.

UHRF1 is essential for proper cytoplasmic architecture and function of mouse oocytes and derived embryos.

Novel compound heterozygous mutations in <i>UHRF1</i> are associated with atypical immunodeficiency, centromeric instability and facial anomalies syndrome with distinctive genome-wide DNA hypomethylation

The UHRF protein family in epigenetics, development, and carcinogenesis.

Identification of SLC38A7 as a Prognostic Marker and Potential Therapeutic Target of Lung Squamous Cell Carcinoma

Interplay between Histone and DNA Methylation Seen through Comparative Methylomes in Rare Mendelian Disorders

Chromatin remodeling in replication-uncoupled maintenance DNA methylation and chromosome stability: Insights from ICF syndrome studies

Ddhd1 knockout mouse as a model of locomotive and physiological abnormality in familial spastic paraplegia

Identification of SLC38A7 as a Prognostic Marker and Potential Therapeutic Target of Lung Squamous Cell Carcinoma

Chromatin remodeling in replication-uncoupled maintenance DNA methylation and chromosome stability: Insights from ICF syndrome studies

Serine 298 Phosphorylation in Linker 2 of UHRF1 Regulates Ligand-Binding Property of Its Tandem Tudor Domain

CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats

Collaborators (8)

Hiroyuki Sasaki

Takako Takano

Wan Kin Au Yeung

Atsuo Ogura

Yoshihiko Kobayashi

Claire Francastel

Haruhiko Koseki

Kyohei Arita

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