Naomi Chesler

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Professor/Director

University of California, Irvine

United States

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Naomi Chesler is a Professor and Director at the University of California, Irvine, specializing in cardiovascular research and pulmonary hemodynamics. Her recent work includes exploration of wave intensity analysis in pulmonary hypertension and investigations into branching patterns in pulmonary arteries. With a focus on multi-scale modeling and uncertainty quantification, she aims to address social determinants of health and disparitites in cardiovascular function. Professor Chesler actively contributes to the field through her research and publications in mechanistic modeling and analysis.

Recent Grants

Grant: Close

Multiscale computational modeling of right ventricular failure

Open Date: 2020-07-01

Close Date: 2025-06-30

Grant: Close

Mechanobiological mechanisms of pulmonary hypertension secondary to left heart failure

Open Date: 2020-06-01

Close Date: 2024-04-30

Grant: Close

The 2019 Big 10 Women's Workshop (BTWW): Closing the Mentoring Loop

Open Date: 2019-02-01

Close Date: 2021-01-31

Grant: Close

Pulmonary Hypertension Associated with Sickle Cell Disease

Open Date: 2016-04-01

Close Date: 2019-03-31

Grant: Close

Novel Computational Models of the Lung Vasculature and Airways Validated with Experiments

Open Date: 2015-10-01

Close Date: 2016-02-01

Articles (22)

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Collaborators (13)

Mitchel Colebank

Assistant Professor

University of South Carolina

UNITED STATES

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Oliver Wieben

UNITED STATES

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Pim Oomen

Assistant Professor

University of California, Irvine

UNITED STATES

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Daniel A Beard

Medical College of Wisconsin

UNITED STATES

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Shelly Peyton

Professor

University of Massachusetts Amherst

UNITED STATES

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Megan Killian

University of Michigan

UNITED STATES

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Cassady Rupert

Chief Scientific Officer

UNITED STATES

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Farhan Raza

UNITED STATES

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Stuart G. Campbell

Yale University

UNITED STATES

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Anthony Baker

University of California

UNITED STATES

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Andrea Frump

Assistant Professor

Indiana State University

UNITED STATES

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Ana Maria Porras

Assistant Professor

University of Florida

UNITED STATES

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Mette S. Olufsen

UNITED STATES

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Naomi Chesler

Research Interests

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About

Recent Grants

Articles (22)

Ca2+ increases cardiac muscle viscoelasticity independent of active force development

Wave intensity analysis with exercise identifies impairments in pulmonary hypertension

Revisiting Murray's Law in Pulmonary Arteries: Exploring Branching Patterns and Principles

Bayesian parameter inference and uncertainty quantification for a computational pulmonary hemodynamics model using Gaussian processes

Response to comments and opinions by Kremer et al regarding our original manuscript “Volume calibration with cardiac MRI vs hypertonic saline for right ventricular pressure-volume loops with exercise: Impact on ventricular function and ventricular-vascular coupling”

Role of Characteristic Pulmonary Impedance With Exercise for Detection of Abnormal Pulmonary Vascular Response and Uncoupling in Pulmonary Hypertension Resulting From Heart Failure With Preserved Ejection Fraction

How multi-scale modeling can help examine social determinants of health and resulting disparities

Guidelines for assessing ventricular pressure-volume relationships in rodents

Guidelines for mechanistic modeling and analysis in cardiovascular research

Efficient uncertainty quantification in a spatially multiscale model of pulmonary arterial and venous hemodynamics

Subject-specific one-dimensional fluid dynamics model of chronic thromboembolic pulmonary hypertension

Equitable hiring strategies towards a diversified faculty

Biventricular Interaction During Acute Left Ventricular Ischemia in Mice: A Combined In-Vivo and In-Silico Approach

You Can’t Spell Shear without “She”: Mechanobiology and Sex Differences in Hypoxic Lung Disease

Increased length-dependent activation of human engineered heart tissue after chronic α1A-adrenergic agonist treatment: testing a novel heart failure therapy

Estrogen Receptor-α Exerts Endothelium-Protective Effects and Attenuates Pulmonary Hypertension

Biomechanical and Mechanobiological Drivers of the Transition From PostCapillary Pulmonary Hypertension to Combined Pre−/PostCapillary Pulmonary Hypertension

Distensibility, an Early Disease Marker of Pulmonary Vascular Health: Ready for Clinical Application

The stronger sex, until menopause: understanding the impact of estrogen loss on heart function

Diffuse Myocardial Fibrosis at Cardiac MRI in Young Adults Born Prematurely: A Cross-sectional Cohort Study

Sex differences in right ventricular adaptation to pressure overload in a rat model

Numerical predictions of shear stress and cyclic stretch in pulmonary hypertension due to left heart failure

Collaborators (13)

Mitchel Colebank

Oliver Wieben

Pim Oomen

Daniel A Beard

Shelly Peyton

Megan Killian

Cassady Rupert

Farhan Raza

Stuart G. Campbell

Anthony Baker

Andrea Frump

Ana Maria Porras

Mette S. Olufsen

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