Naoto Kojima

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Professor

Nagasaki University

Japan

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Recent Grants

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新規抗がん剤の創製を指向したアセトゲニン誘導体のTHF環部分の構造活性相関研究

Open Date: 2016-04-01

Close Date: 2023-03-31

Grant: Close

Structure activity relationships study of dual-core type acetogenin analogues for development of novel antitumor agents

Open Date: 2013-04-01

Close Date: 2017-03-31

Grant: Close

Basic studies of therapeutic modality for polycystic kidney disease explored by epigenetic modification of cellular matrix-adhesion proteins

Open Date: 2012-04-01

Close Date: 2015-03-31

Grant: Close

Structure-activity relationship study of hybrid acetogenins toward the practical use

Open Date: 2011-01-01

Close Date: 2012-12-31

Grant: Close

Development of novel synthetic reactions based on release of strain energy in small ring system and its application to total syntheses of natural products

Open Date: 2010-04-01

Close Date: 2013-03-31

Articles (10)

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (2)

Kenji Arimitsu

Osaka University

JAPAN

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Takashi Shigeta

Lecturer

Gifu Pharmaceutical University

JAPAN

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Naoto Kojima

Research Interests

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Recent Grants

Articles (10)

Thiophene Carboxamide Analogs with Long Alkyl Chains Comprising Ethylene Glycol Units Inhibit Glioblastoma Cell Proliferation by Activating AMPK

Facile synthesis of 5-alkoxy-4-aryltetrahydrofuran-2-one using hypervalent iodine reagents

Synthesis of Acetogenin Analogs Comprising Pyrimidine Moieties Linked by Amine Bonds and Their Inhibitory Activity against Human Cancer Cell Lines

JCI‑20679 suppresses the proliferation of glioblastoma stem cells by activating AMPK and decreasing NFATc2 expression levels

JCI-20679 suppresses autophagy and enhances temozolomide-mediated growth inhibition of glioblastoma cells

Chemical structures and induction of cell death via heat shock protein inhibition of the prenylated phloroglucinol derivatives isolated from Hypericum erectum

Construction of sulfur-containing compounds with anti-cancer stem cell activity using thioacrolein derived from garlic based on nature-inspired scaffolds

Structure–antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety

Construction of Acyclic All-Carbon Quaternary Stereocenter Based on Asymmetric Michael Addition of Chiral Amine

Structure–Activity Relationships of Thiophene Carboxamide Annonaceous Acetogenin Analogs: Shortening the Alkyl Chain in the Tail Part Significantly Affects Their Growth Inhibitory Activity against Human Cancer Cell Lines

Collaborators (2)

Kenji Arimitsu

Takashi Shigeta

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