Natalia Skrzypczak

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Adam Mickiewicz University in Poznań

Poland

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Recent Grants

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Targeted Degradation of the MLL Complex in Leukemia: A PROTAC-Based Therapeutic Strategy

Open Date: 2025-01-01

Close Date:

Grant: Close

Heterocyclization of benzenoid ansamycins core as useful strategy for designing anticancer agents

Open Date: 2022-01-01

Close Date: 2023-01-01

Articles (8)

Year:

2025

Year:

2023

Year:

2023

Year:

2022

Year:

2022

Year:

2022

Year:

2021

Year:

2020

Collaborators (5)

Chandan Guha

Professor and Vice Chair

Montefiore Medical Center

UNITED STATES

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Piotr Przybylski

Full Professor of Chemistry

Uniwersytet im Adama Mickiewicza w Poznaniu Wydział Chemii

POLAND

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Alicja Rajtak

Medical University of Lublin

POLAND

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Piotr Ruszkowski

Poznan University of Medical Sciences

POLAND

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Maria Gdaniec

Professor

Uniwersytet im Adama Mickiewicza w Poznaniu Wydział Chemii

POLAND

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Natalia Skrzypczak

Research Interests

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Recent Grants

Articles (8)

Therapy resistance: Modulating evolutionarily conserved heat shock protein machinery in cancer

Cascade Transformation of the Ansamycin Benzoquinone Core into Benzoxazole Influencing Anticancer Activity and Selectivity

Modifications of geldanamycin via CuAAC altering affinity to chaperone protein Hsp90 and cytotoxicity

Regioselective approach to colchiceine tropolone ring functionalization at C(9) and C(10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs

Modifications, biological origin and antibacterial activity of naphthalenoid ansamycins

Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners

Anticancer activity and toxicity of new quaternary ammonium geldanamycin derivative salts and their mixtures with potentiators

Synthesis, structure and anticancer activity of new geldanamycin amine analogs containing C(17)- or C(20)- flexible and rigid arms as well as closed or open ansa-bridges

Collaborators (5)

Chandan Guha

Piotr Przybylski

Alicja Rajtak

Piotr Ruszkowski

Maria Gdaniec

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